Placental pathology in spontaneous abortions: a study with review of literature.
Keywords:
Abortion, Retained, Perfusion defects, Pregnancy, Trophoblasts, InfertilityAbstract
Background: Retained products of conception’ are quite a frequent specimen received for histopathological examination. Apart from confirmation of pregnancy, a careful examination can provide some additional information about the cause or the conditions associated with abortion.
Methods: A total of 53 cases were studied over a period of 1 year (from June 2014 to May 2014). The specimens were received in formalin, kept for fixation and stained with Haematoxylin and Eosin.
Results: Thirty out of fifty-three cases showed significant positive findings. Maternal perfusion defects were the most common (80%); of which, ischemia related defects were the most frequent ones (87.5%). The other findings included maternal floor infarction, chronic histiocyticintervillositis and persistent muscularization of basal plate arteries. Fetal perfusion defects constituted of three cases (10%) in which avascular villi were seen in two cases and chorangiosis was seen in one case. One case each of partial mole, complete mole and gestational trophoblastic neoplasm was also found in the study.
Conclusion: The present study highlights few of the histopathological findings observed in such specimens, which might help in predicting future pregnancy outcome and in planning the family accordingly.
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Copyright (c) 2016 Kriti Chauhan, Manish Chaudhary, Monika Garg, Ridhima Auplish, Karuna Sangwan, Nanak Mahajan
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