Wilms tumour with neural differentiation: A rare histological presentation
Keywords:
Wilm's Tumor, Neural Differentiation, WT1, SynaptophysinAbstract
Wilm's tumour is the most common malignant renal tumour of childhood presenting most commonly between the age groups of 1 to 6 years. It exhibits histogenetic heterogeneity. A 4 year old female child presented with complaints of right abdominal pain and mass per abdomen for the past six months .The patient underwent right sided nephrectomy and the specimen was sent for histopathological examination .Cut surface of the tumour was variegated with extensive areas of necrosis and haemorrhage On microscopy the tumour cells were predominantly blastematous , arranged as diffuse sheets of tumor cells with focal nesting pattern in some areas. Tumour cells showed diffuse anaplasia.
These tumour cells showed positivity for WT1 ,vimentin, synaptophysin and p53. No evidence of any epithelial or stromal differentiation was noted. Findings suggested a diagnosis of monophasic variant( blastemal) Wilm's tumor with neural differentiation.
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