Membranous Nephropathy: A Rare Association With Renal Vein Thrombosis
Keywords:
Membranous Nephropathy, Renal Vein Thrombosis, Nephrotic SyndromeAbstract
Background: Thromboembolic events are a known complication of nephrotic syndrome and occur with a frequency varying from 10% to 45% depending upon the underlying disease.
Case Presentation: A 25 year male presented with history of decreased urine output , groin pain and edema lower limbs. Laboratory tests showed Urea 30mg/dL; Creatinine 0.66mg/dL; albumin 2.3g/dL; proteinuria 3+ and negative viral serology. An abdominal ultrasound with Doppler showed features suggestive of partial revascularization. Renal biopsy showed membranous nephropathy.
Conclusion: Our case shows that renal vein thrombosis (RVT) is a complication of membranous nephropathy.
References
2. Daher EF, Junior GBS, Galdino GS, Eduardo DS, Wanderley TP, Lopes TS. Renal Vein Thrombosis and Membranous Nephropathy – Report of 2 Cases. J Medicine 2011; 12:73-6.
3. Andrassy K, Ritz E, Bommer J. Hypercoagulability in the nephrotic syndrome. Klin Wochenschr 1980; 58: 1029-36.
4. Llach F, Papper S, Massry SG. The clinical spectrum of renal vein thrombosis: acute and chronic. Am J Med 1980; 69: 819-27.
5. Radhakrishnan J. Venous Thromboembolism and Membranous Nephropathy: So What’s New? Clin J Am Soc Nephrol 2012; 7: 3–4.
6. Cade R, Spooner G, Juncos L, Fuller T, Tarrant D, Raulerson D, et al. Chronic renal vein thrombosis. Am J Med 1977; 63: 387-97.
7. Wagoner RD, Stanson AW, Holley KE, Winter CS: Renal vein thrombosis in idiopathic membranous glomerulopathy and nephritic syndrome: incidence and significance. Kidney Int 1983; 23: 368–74.
8. Llach, F. Hypercoagulability, renal vein thrombosis, and other thrombotic complications of nephrotic syndrome. Kidney Int 1985; 28: 429-39.
9. Glen S. Markowitz Membranous Glomerulopathy: Emphasis on Secondary Forms and Disease Variants. Adv Anat Pathol. 2001 May;8(3):119-25.
10. Singhal, R, Brimble, KS. Thromboembolic complications in the nephrotic syndrome: pathophysiology and clinical management. Thromb Res 2006; 118: 397-407.
11. Glassock RJ: Prophylactic anticoagulation in nephrotic syndrome: A clinical conundrum. J Am Soc Nephrol 2001; 18: 2221–5.
12. Kendall AG, Lohmann RC, Dossetor JB: Nephrotic syndrome. A hypercoagulable state. Arch Intern Med 1971;127: 1021–7.
13. Markowitz GS, Brignol F, Burns EB, et al. Renal vein thrombosis treated with thrombolytic therapy: case report and brief review. Am J Kidn Dis 1995;25(5):801–6.
14. Wu CH, Ko SF, Lee CH, Cheng BC, Hsu KT, Chen JB, et al. Successful outpatient treatment of renal vein thrombosis by low-molecular weight heparins in 3 patients with nephrotic syndrome. Clin Nephrol 2006; 65: 433-40
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Copyright (c) 2016 Ankur Mittal, Ruchi Gupta, Pavneet Selhi, Harpreet Kaur, Neena Sood, Jasvinder Sandhu
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