The Histopathological and Epidemiological Study of Pediatric Brain Tumors in a Tertiary Care Hospital, Mumbai
Keywords:
Astrocytoma, epidemiology, medulloblastoma, pediatric brain tumorAbstract
Background: The primary pediatric brain tumors (PBT) are the second most common cause of death due to malignancies in children. This study was done to analyze the histological spectrum of primary brain tumors in children and also to find out the epidemiology of the common pediatric brain tumors.
Methods: Data regarding age, gender, topography, and histopathology of 239 pediatric patients (0–18 years) with brain tumors operated over a period of 15 years (January-2001 to December-2015) was collected and analyzed according to World Health Organization 2007 classification
Result: PBTs were more common in males (54.8%) as compared to females (45.2%) with male to female ratio of 1.21:1. Frequency of tumors was higher in childhood age group (>5-<15 years) i.e. (55.6%) when compared to adolescent age group (15.9%). The most common anatomical site was cerebellum (40.5%), followed by hemispheres (21.4%). Supratentorial tumors (51.9%) were predominant than infratentorial tumors (45.2%) and 2.9% at spinal location. Astrocytomas (46.8%) and embryonal tumors (18.4%) were the most common histological types followed by ependymal tumors (12.5%) and craniopharyngiomas (9.2%). Medulloblastoma was the most common histological type with pilocytic astrocytoma being most common astrocytic tumor. In comparison to adults, meningiomas and lymphomas were rare in children.
Conclusion: Astrocytomas and medulloblastomas are the most common tumors among children and adolescents in our region. Except for a slightly higher frequency of craniopharyngiomas, the histological profile of pediatric brain tumors in India is similar to that reported in the Western literature.
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Copyright (c) 2016 Sangita Margam, Nitin Maheshwar Gadgil, Ganesh Ramdas Kshirsagar, Vaishali Prashant Gaikwad, Prashant Vijay Kumavat, Chetan Sudhakar Chaudhari
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