Association of thyroid disorders with the hormones of anterior pituitary in female infertiltiy

Authors

  • Rakhee Yadav FMHS, SGT University, Gurgaon
  • Sanjiv Kumar Bansal FMHS, SGT University, Gurgaon
  • Busi Karunanand FMHS, SGT University, Gurgaon
  • Eram Hussain Pasha FMHS, SGT University, Gurgaon
  • Birendra Kumar Yadav FHMS, SGT University, Gurgaon
  • Smita Prasad Shastry FMHS, SGT University, Gugaon

Keywords:

infertility, females, hypothyroidism, prolactin, LH, FSH

Abstract

Background: Fertility in femalesis centred on the functionalhypothalamo-pituitary-ovarian (HPO) axis. Thyroid dysfunctions are also known to interfere with the physiology of reproduction and pregnancy. This study was conducted with an objective to evaluate the relationship between thyroid and pituitary hormones in female infertility because abnormalities of HPO axis and thyroid dysfunction are one of the common and often treatable causes of infertility in females.

Methods: Hundred female patients of infertility who visited the Department of Biochemistry, SGT Medical College, Hospital and Research Institute, Gurgaon for hormonal evaluation were recruited for the study. After excluding other causes of infertility including tubal factors, genetic or other anatomical factors; blood samples for TSH, LH, FSH and Prolactin were collected. Hundredage matched healthy fertile females were recruited as controls and their blood samples were collected for similar hormone assay. These parameters were estimated by the ELISA technique. Results were statistically analysed.

Result: Out of the patients in our study group, 78% had primary infertility while secondary infertility was seen in 22% of the patients. Majority of the patients came out to be euthyroid (79%). There was a significant (p value<0.05) high serum level of Prolactin in patients of infertility as compared to controls. LH and FSH were found to be lower in infertile patients as compared to healthy controls. Moreover there was a significant positive correlation between the levels of TSH and Prolactin in infertile patients thus it might be imperative to say that hypothyroidism was strongly associated with hyperprolactinemia.

Conclusion: For the normal physiology of reproduction, the functions of pituitary as well as thyroid should be normal. From our study we have elucidated that abnormalities of the thyroid gland and pituitary gland are interrelated. Thus their evaluation becomes necessary in order to elucidate the etiopathogenesis of female infertility which will further enhance the dimension towards designing effective treatment protocols.

Author Biographies

Rakhee Yadav, FMHS, SGT University, Gurgaon

Assistant Professor, Department of Biochemistry, FMHS, SGT University, Gurgaon (Haryana)

Sanjiv Kumar Bansal, FMHS, SGT University, Gurgaon

associate professor, deptt of Biochemistry, FMHS, SGT University, Gurgaon

Busi Karunanand, FMHS, SGT University, Gurgaon

Professor and Head, Deptt of Biochemistry, FMHS, SGT University, Gurgaon

Eram Hussain Pasha, FMHS, SGT University, Gurgaon

MD student, Deptt of Biochemistry, FMHS, SGT University, Gurgaon

Birendra Kumar Yadav, FHMS, SGT University, Gurgaon

PhD student, FMHS, SGT University, Gurgaon

Smita Prasad Shastry, FMHS, SGT University, Gugaon

PhD student, Deptt of Biochemistry, FMHS, SGT University, gurgaon

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Published

26-10-2016

How to Cite

1.
Yadav R, Bansal SK, Karunanand B, Pasha EH, Yadav BK, Shastry SP. Association of thyroid disorders with the hormones of anterior pituitary in female infertiltiy. Ann of Pathol and Lab Med [Internet]. 2016 Oct. 26 [cited 2025 Feb. 6];3(4):A340-346. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm848

Issue

Vol. 3 No. 4 (2016)

Section

Original Article

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Copyright (c) 2016 Rakhee Yadav, Sanjiv Kumar Bansal, Busi Karunanand, Eram Hussain Pasha, Birendra Kumar Yadav, Smita Prasad Shastry

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