Documentation of Myeloproliferative Disorder as the Commonest Hematological Malignancy in Predominant Rural Based Pilot Study at Punjab (India): An Incidental Finding or Association.

Authors

  • Rahul Mannan Department of Pathology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar , Punjab, India
  • Mridu Manjari Department of Pathology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar , Punjab, India
  • Sonam Sharma Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
  • Komalpreet Bhatia Department of Pathology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar , Punjab, India
  • Gagandeep Singh Department of Pathology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar , Punjab, India
  • Tejinder Bhasin Department of Pathology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar , Punjab, India

Keywords:

Bone marrow, India, Malignancy, Punjab, Spectrum

Abstract

Background: Pilot studies (standard scientific tool) are helpful for researchers in conducting preliminary analysis before committing resources for a main study to follow. The present pilot study was undertaken in the northern part of India so as to take a glimpse of the pattern of hematological malignancies in an area which is mostly based on the agricultural economy and the hazards associated with it. These demographic based studies are often helpful in defining the burden and to ascertain the trends of the disease in the selected population.

Method: A 3 year retrospective study was conducted in the hematopathology unit of the Department of Pathology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab (India) from a period of January 2012 to December 2014. Data regarding demographic/epidemiological details including clinical presentation, indication for the procedure was noted. Only the cases of hematological malignancies were included in the study. The results thus obtained were recorded and analyzed by descriptive statistics.

Results: Of 1840 cases, 147 (7.98%) were hematological malignancies with Male to Female ratio being 2:1. After retrieving the residential records, it was noted that most of the patients were natives of Punjab state. The most common peripheral blood finding in hematological malignancies cases were pancytopenia ( 38.09 % )  , followed by bicytopenia ( 27.2 % ). According to the clinical presentation most common presentation recorded was hepatomegaly (42.1%), followed by splenomegaly (28.57%). The commonest hematological malignancy in our study was MPD (Chronic Myeloid Leukaemia primarily) followed by Lympho-proliferative disorders (which included Chronic Lymphocytic Leukaemia, Non Hodgkin’s Lymphoma and Hairy Cell Leukaemia). Combining both the categories, the so called chronic leukaemias contributed almost 2/3 of cases (72.78%).

Conclusions:  In contrast to most of the reported institutional based cases from India and the neighboring countries (including many developing countries of Asia) which have recorded acute leukaemia (ALL/AML) overall as the most common hematological malignancy ; the higher incidence of chronic leukaemias in our study is interesting.

The finding of CML as more common of the chronic leukaemias in comparison to the CLL and other LPD’s is noteworthy. This trend needs to be watched carefully and a further study is planned to monitor the overall outcome over the next few years. 

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Published

24-08-2016

How to Cite

1.
Mannan R, Manjari M, Sharma S, Bhatia K, Singh G, Bhasin T. Documentation of Myeloproliferative Disorder as the Commonest Hematological Malignancy in Predominant Rural Based Pilot Study at Punjab (India): An Incidental Finding or Association. Ann of Pathol and Lab Med [Internet]. 2016 Aug. 24 [cited 2024 Nov. 19];3(3):A237-243. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm871

Issue

Vol. 3 No. 3 (2016)

Section

Original Article

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Copyright (c) 2016 Rahul Mannan, Mridu Manjari, Sonam Sharma, Komalpreet Bhatia, Gagandeep Singh, Tejinder Bhasin

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