Evaluation of small intestinal biopsies in malabsorption syndromes

Authors

  • Ashmeet Kaur Santokba durlabhji memorial hospital,jaipur Rajasthan
  • Poojaba Jadeja
  • Neha Garg
  • SML Rai
  • N Mogra

Keywords:

Malabsorption, Celiac Disease, Chronic diarrhea, Non specific duodenitis, Villous atrophy

Abstract

Backgound: The gold standard test for evaluation of  intestinal malabsorption is biopsy. The various yet similar, abnormal mucosal architecture patterns  in intestinal malabsorption makes it difficult for the pathologist to report its etiological cause

Methods-We analyzed the clinical presentation, endoscopic and histological features of 328 consecutive patients  with complaints suggestive of  malabsorption syndrome. The spectrum of disease in these patients were studied and divided into four groups on the basis of histologic features and correlated with clinical/endoscopic findings

Results: Group1 were entities usually associated with a diffuse severe villous abnormality and crypt  hyperplasia ,all 57 cases were of  celiac disease (17.3%), Group 2 were entities usually associated with a variable villous abnormality and crypt hypoplasia, included 7 cases-malnourished 5(1.5%) and post chemotherapy 2(0.6%), Group 3 were entities usually associated with a nonspecific variable villous abnormality, usually not flat included  252 biopsies- Tropical sprue 16(4.8%), nonspecific duodenitis/jejunitis/ileitis 212 (64.6%), peptic duodenitis 16(4.8%), intestinal tuberculosis 8 (2.43%), and in Group 4 were entities associated with variable villous abnormalities illustrating specific diagnostic changes included 12 cases-giardiasis 2 (0.6%), Crohn’s disease 8 (2.4%), intestinal lymphangiectasia 1 (0.3%), lymphoma 1(0.34%).

References

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Published

06-11-2016

How to Cite

1.
Kaur A, Jadeja P, Garg N, Rai S, Mogra N. Evaluation of small intestinal biopsies in malabsorption syndromes. Ann of Pathol and Lab Med [Internet]. 2016 Nov. 6 [cited 2024 Nov. 19];3(5):A408-414. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm895

Issue

Vol. 3 No. 5 (2016): (Suppl) November

Section

Original Article

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Copyright (c) 2016 Ashmeet Kaur, Poojaba Jadeja, Neha Garg, SML Rai, N Mogra

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