Late relapse of malignant peripheral nerve sheath tumor after 18 years. Case report with differential diagnosis.
Keywords:
MPNS, differential diagnosis, immunohistochemistry, molecular geneticsAbstract
Malignant mesenchymal tumors represent a heterogeneous group of neoplasms. Diagnostics is based on a comprehensive clinical and pathological assessment that takes into account the results of imaging methods and molecular genetics. The exact diagnosis of these neoplasms is important for their subsequent therapeutic management. Authors describe a case of a 47-year-old female patient with poorly differentiated sarcoma in the left neck region which they, based on histomorphological features, a wide immunohistochemistry panel, and detailed history, diagnosed as a late recurrence of MPNST 18 years after the primary diagnosis. Tumors of the Ewing sarcoma/PNET, synovial sarcoma, which have similar histomorphological features, were excluded in the process of differential diagnostics. MPNST is characterized as a malignant tumor with unpredictable biological behavior, and as the case described above indicates, it may even return many years after the primary diagnosis.Â
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Copyright (c) 2016 Csaba Biró, KatarÃna Macháleková, Å tefan Galbavý, Gabriel Bognár, Sarah Catharina Hubinská, Martin Kopáni, Karol Kajo, Dagmar Kalátová
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