Persistent eosinophilia in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma and TP53 deletion is a potential predictor of variant Richter’s transformation

Authors

  • Madhu M Ouseph Department of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
  • James N Butera Division of Hematology/Oncology, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
  • Rogers C Griffith Department of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
  • Dariusz Stachurski Department of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
  • Diana Olguta Treaba Department of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

Keywords:

Eosinophilia, chronic lymphocytic leukemia, small lymphocytic lymphoma, classical Hodgkin lymphoma

Abstract

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) progression to diffuse large B-cell lymphoma (Richter’s syndrome) is noted in approximately 3 - 16% of the patients. However, transformation to classical Hodgkin lymphoma occurs in only 0.5% of the patients and has no clinically well-defined predictors. We report three patients with CLL/SLL and TP53 deletion in whom persistent eosinophilia preceded the Hodgkin lymphoma transformation

Author Biographies

Madhu M Ouseph, Department of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

Department of Pathology and Laboratory Medicine

Residents, PGY-3

James N Butera, Division of Hematology/Oncology, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

Associate Professor, Division of Hematology/Oncology

Rogers C Griffith, Department of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

Associate Professor, Department of Pathology

Dariusz Stachurski, Department of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

Assistant Professor, Department of Pathology

Diana Olguta Treaba, Department of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

Department of Pathology and Laboratory Medicine

Director, Hematopathology

Associate Professor of Pathology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

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Published

03-10-2016

How to Cite

1.
Ouseph MM, Butera JN, Griffith RC, Stachurski D, Treaba DO. Persistent eosinophilia in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma and TP53 deletion is a potential predictor of variant Richter’s transformation. Ann of Pathol and Lab Med [Internet]. 2016 Oct. 3 [cited 2025 Feb. 6];3(4):C212-216. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm994

Issue

Vol. 3 No. 4 (2016)

Section

Case Report

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Copyright (c) 2016 Madhu M Ouseph, James N Butera, Rogers C Griffith, Dariusz Stachurski, Diana Olguta Treaba

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