Unusual occurrence of Ewings sarcoma/PNET with pregnancy: 2 cases and literature review.

Authors

  • Kumarbhargav R Kaptan Toprani Advanced Lab system, Vadodara, Gujarat
  • Vasudha M Bhagat Additional professor in G.M.E.R.S. medical college, Valsad, Gujarat.
  • Reena B Dudhat Consultant Pathologist at Private hospital, Surat, Gujarat
  • Sonal L Italiya Consultant Pathologist at BAPS hospital, Surat, Gujarat
  • Miteshkumar B Shah Consultant Pathologist at Toprani Advanced Lab System, Vadodara, Gujarat

Keywords:

Ewing’s sarcoma, PNET, Pregnancy, Sarcoma,

Abstract

The occurrence of cancer in a pregnant woman is a relatively low-probability event. The influence of pregnancy on the initiation, promotion and development of sarcomas is yet unclear. Epidemiological data suggest that the incidence of cancer during pregnancy is 0.07% to 0.1% of all malignant tumours. To our knowledge, only few cases of Ewing's sarcoma/PNET developing during pregnancy have been described.  The treatment approach is strongly influenced by the type and site of the primary tumour, its growth rate and associated symptoms, and by the need to treat the woman while minimizing foetal toxicity. Here we describe two cases of Ewing's sarcoma/PNET in a pregnant woman, in whom the diagnostic and therapeutic approaches were tailored in order to cure the patient and to avoid unnecessary toxicity to the foetus. One out of  two  patients  underwent abortion and other successfully delivered baby before receiving treatment for underlying  sarcoma.

Author Biographies

Kumarbhargav R Kaptan, Toprani Advanced Lab system, Vadodara, Gujarat

Consultant Pathologist at Toprani Advanced Lab System, Vadodara.

Vasudha M Bhagat, Additional professor in G.M.E.R.S. medical college, Valsad, Gujarat.

Additional professor

Reena B Dudhat, Consultant Pathologist at Private hospital, Surat, Gujarat

Consultant Pathologist

Sonal L Italiya, Consultant Pathologist at BAPS hospital, Surat, Gujarat

Consultant Pathologist

Miteshkumar B Shah, Consultant Pathologist at Toprani Advanced Lab System, Vadodara, Gujarat

Consultant Pathologist

References

1. Merimsky O, LeCesne A. Soft tissue and bone sarcoma in association with pregnancy. ActaOncol 1998; 37:721-7.
2. Merimsky O, Le Chevalier T, Missenard G, Lepechoux C, Cojean-Zelek I, Mesurolle B, et al: Management of cancer in pregnancy: a case of Ewing’s sarcoma of the pelvis in the third trimester. Ann Oncol 1999; 10:345-50.
3. Azim H, Peccatori F, Pavlidis N. Treatment of the pregnant mother with cancer: a systematic review on the use of cytotoxic, endocrine, targeted agents and immunotherapy during pregnancy. Part I: Solid tumors. Cancer Treat Rev 2010;36:101-9.
4. Brewer M, Kueck A, Runowicz C. Chemo-therapy in pregnancy. ClinObstetGynecol 2011; 54:602-18.
5. Hogendoorn PC, Athanasou N, Bielack S, De Alava E, Dei Tos AP, Ferrari S, et al. Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010;21:204-13.
6. Weiss &Goldblum.Enzinger and Weiss's Soft Tissue Tumors, 5th ed. St. Louis, Mosby Elesevier. 2008.
7. Doll DC, Scott Ringenberg Q, Yarbro JW. Antineoplastic agents and pregnancy. Semin Oncol 1989;16:337–46.
8. Lysyj A, Bergquist JR. Pregnancy complicated by sarcoma. Report of two cases. ObstetGyencol 1963; 21:506-9.
9. Haerr RW, Pratt AT.Multiagent chemotherapy for sarcoma diagnosed during pregnancy. Cancer 1985; 56:1028-33.
10. Nakajima W, Ishida A, Takashi M, Hirayama M, Washino N, Ogawa M, et al: Good outcome for infant of mother treated with chemotherapy for Ewing sarcoma at 25 to 30 week’s gestation. J PediatrHematol Oncol 2004; 26:308-11
11. Ateser G, Yildiz O, Leblebici C, Mandel NM, Unal F, Turna H, et al: Metastatic primitive neuroectodermal tumor of the ovary in preg-nancy. IntJ Gynecol Cancer 2007; 17:266-9.
12. Taylor HB, Helwig EB. Dermatofibrosarcoma protuberans: a study of 115 cases. Cancer 1962;15:717–25.
13. Goyal P, Agrawal D, Sehgal S, Ghosh S, Kumar A, Singh S. Aggressive angiomyxoma in pregnancy. Rare Tumors 2014;6:63-4.
14. Albrektsen G, Heuch E, Tretli S, Kvale G. Is the risk of cancer of the corpus uteri reduced by a recent pregnancy? Int J Cancer 1995; 61: 485-90.
15. Sahel JA, Earle JD, Albert DM. Intraocular melanoma. In: DeVita VT, Hellman S, Rosenberg SA, (eds.) Cancer principles and practice of oncology. Philadelphia: Lippincott, 1993: 1662–78.
16. Nieminen V, Remes N. Malignancy during pregnancy. ActaObstetGynecolScand 1970; 49: 315–8.
17. Merimsky O, Le Chevalier T, Missenard G, Lepechoux C, Cojean-Zelek I, Mesurolle B, et al. Management of cancer in Pregnancy: A case of Ewing’s sarcoma of the pelvis in the third trimester. Ann Oncol. 1999;10:345-50.

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Published

28-09-2014

How to Cite

1.
Kaptan KR, Bhagat VM, Dudhat RB, Italiya SL, Shah MB. Unusual occurrence of Ewings sarcoma/PNET with pregnancy: 2 cases and literature review. Ann of Pathol and Lab Med [Internet]. 2014 Sep. 28 [cited 2024 Dec. 27];1(2):C5-C9. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/20

Issue

Vol. 1 No. 2 (2014): Oct-Dec

Section

Case Report

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Copyright (c) 2014 Kumarbhargav R Kaptan, Vasudha M Bhagat, Reena B Dudhat, Sonal L Italiya, Miteshkumar B Shah

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