Role of P53 Expression in Pterygium in Natives from Hilly Area
DOI:
https://doi.org/10.21276/apalm.2058Keywords:
P53, PTERYGIUM, HILLYAbstract
BACKGROUND: Pterygium has been considered an ocular degenerative fibrovascular neoformation for long but abnormal p53 expression reinforces the theory that it is a proliferative condition like a tumor. The present study was aimed to describe the pattern of p53 immunoexpression in pterygium.
MATERIAL AND METHODS: We included 50 excised pterygium and 10 normal conjunctival control specimens, processed for histopathology and immunostaining for p53. Cut-off value of p53 expression was taken as 5% epithelial cell positivity.
RESULTS: We found higher incidence of pterygium in females and statistically significant positive p53 expression in 38 cases (76%) as compared to control group. No significant association between variations in clinical grade or histological features and abnormal p53 expression in cases and control groups was found.
CONCLUSION: p53 overexpression in pterygium suggests that pterygium is a proliferative tissue disorder.
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Copyright (c) 2018 Kaushik Sanjay, Thakur Brijesh, Kishore Sanjeev, Kala Pooja
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