A Study of Hematological Changes in Dengue Patients at A Tertiary Care Hospital, Bhavnagar, Gujarat
DOI:
https://doi.org/10.21276/apalm.2163Keywords:
Dengue fever, Thrombocytopenia, LeucopeniaAbstract
Background: Dengue is one of the most common arthropod-borne viral (arboviral) illness in humans. It is transmitted by mosquitoes of the genes aedes-principally aedes aegypti. Present study focuses on the haematological changes in serologically proven dengue positive patients in tertiary care hospital.
Methods:
Retrospective observational study was conducted amongst NS1antigen/IgM dengue positive dengue patients in a tertiary care hospital for a period of 6 months.Complete hemogram of one hundred patients was studied and analysed.
Result: Out of the 100 patients studied, 65% patients were in 12-30 years age groups and 75% were males. Leucopoenia was noticed in 36% of cases. Thrombocytopenia at presentation was seen in 94 % of cases. Raised liver serum transaminases, predominantly SGOT were found in 16 out of 20 patients.
Conclusion: Fever associated with thrombocytopenia, leucopoenia and elevated liver transaminases should prompt a clinician on the possibility of dengue infection. Platelet transfusions have a little role in management of dengue patients.
References
1.Patel PM, Patel SK, Sabalpara MA, Shah CK, Shah NR. Study of hematological and biochemical changes in dengue fever at tertiary care hospital at Ahmedabad. ijmsph. 2016;5(09):1934-36.
2. Jain A, Shah AN, Patel P et al. A clinico-hematological profile of dengue outbreak among
healthcare professionals in a tertiary care hospital of Ahmedabad with analysis on economic
impact. Nat J Comm Med. 2013;4:286-90.
3. Gubler DJ. The global emergence/ resurgence of arboviral disease as public health problem. Arch
Med Res. 2002;33:330-42.
4. Deshwal R, Qureshi MI, Singh R. Clinical and Laboratory Profile of Dengue Fever. japi. 2015;63:30-
32.
5. Shah GS, Islam S, Das BK. World health Organization. Dengue and dengue haemorrhagic fever.
kumj. (2006);4:40-43.
6.Moideen JCA, Sathikali AS, Syed S. Clinical and hematological parameter in adult dengue patients.
mimj. 2017;4(3):306-309.
7. Vulavala S, Reddy Y, Kamarthy P. Study of clinical and laboratory profile of dengue fever patients.
Ejpm. 2016;3(11):613-616.
8. Ministry of Health & Family Welfare: Guidelines for Clinical Management of Dengue Fever, Dengue
Hemorrhagic Fever and Dengue Shock Syndrome. New Delhi, India: Govt of India; 2008:2-14.
9. World Health Organization (WHO) and the Special Programme for Research and Training in
Tropical Diseases(TDR). Dengue: guidelines for diagnosis, treatment,prevention and control– New
Edition. Geneva, Switzerland. World Health Organisation. 2009:10-14.
10. Chavan SA , Padhiyar R, Kamtalwar S, Darole P. Study of clinical and laboratory predictors of in
hospital outcome in dengue fever in Mumbai city. IJRTSAT. 2016;19(2)304-308.
11. Kumar R, Shanker S, Ranjan R. A clinical and biochemical study of dengue fever in Kosi region of
Bihar, India. IJAM. 2017;4(4):964-967.
12. Narayanan M, Aravind MA, Thilothammal N, Prema R, Sargunam CS, Ramamurty N. Dengue Fever
Epidemic in Chennai - A Study of Clinical Profile and Outcome. Indian Pediatr. 2002;39:1027-1033.
13. Kalayanarooj S, Vaughn DW, Nimmannitya S et al. Early Clinical and Laboratory Indicators of
Acute Dengue Illness. IJID. 1997;176:313–21
14. Choudhary S, B.R Shivkumar , Adisesha S, Y.A. Manjunatha , M.M. Priyadarshini. Haematological
changes in dengue fever. njbms. 2003;III(4 ):289-293.
15. Ali N, Usman M, Syed N, Khurshid M. Haemorrhagic manifestations and utility of haematological
parameters in dengue fever tertiary care centre experience at Karachi. Scand J Infect Dis. 2007;
39:1025-8.
16. Gawoski JM, Ooi WW. Dengue fever mimicking plasma cell leukemia. Arch Pathol Lab Med. 2003;
127(8):1026-7.
17. Roberto da Justa Pires Neto, Saulo Lacerda Borges de Sá et al. Dengue infection in children and
adolescents in northeast Brazil. Rev. Soc. Bras. Med. Trop. 2013;46(6):765-768.
18.Lei HY, Yeh TM, Liu HS, Lin YS, Chen SH, Liu CC. Immuno pathogenesis of dengue virus infection. J
Biomed Sci. 2001;8:377-388.
19.Schexneider KI, Reddy EA. Thrombocytopenia in dengue fever. Curr Hematol Rep. 2005; 4:145-
148.
20.Bhaskar M, Moorthy S, Kumar NS, Arthur P. Dengue haemorrhagic fever among adults – An
Observational study in Chennai, south India. Indian J Med Res. 2010;132(6):738–740.
21.Seneviratne SL, Malavige GN, Silva HJ. Pathogenesis of liver involvement during dengue viral
infections. Trans R Soc Trop Med Hyg. 2006;100:608-614.
22.Silva EM, Conde JN, Allonso D, Nogueira ML, Mohana-Borges R. Mapping the Interactions of
Dengue Virus NS1 Protein with Human Liver Proteins Using a Yeast Two-Hybrid System:
Identification of C1q as an Interacting Partner. PLoS One. 2013;8:e57514.
23.Kularatne SA, Gawarammana IB, Kumarasiri PR. Epidemiology, clinical features, laboratory
investigations and early diagnosis of dengue fever in adults: a descriptive study in Sri Lanka.
Southeast Asian J Trop Med Public Health. 2005;36(3):686-92.
24. Babaliche P, Doshi D. Catching Dengue Early: Clinical Features and Laboratory Markers of Dengue
Virus Infection. J Assoc Physicians India. 2015;63(5):38-41.
2. Jain A, Shah AN, Patel P et al. A clinico-hematological profile of dengue outbreak among
healthcare professionals in a tertiary care hospital of Ahmedabad with analysis on economic
impact. Nat J Comm Med. 2013;4:286-90.
3. Gubler DJ. The global emergence/ resurgence of arboviral disease as public health problem. Arch
Med Res. 2002;33:330-42.
4. Deshwal R, Qureshi MI, Singh R. Clinical and Laboratory Profile of Dengue Fever. japi. 2015;63:30-
32.
5. Shah GS, Islam S, Das BK. World health Organization. Dengue and dengue haemorrhagic fever.
kumj. (2006);4:40-43.
6.Moideen JCA, Sathikali AS, Syed S. Clinical and hematological parameter in adult dengue patients.
mimj. 2017;4(3):306-309.
7. Vulavala S, Reddy Y, Kamarthy P. Study of clinical and laboratory profile of dengue fever patients.
Ejpm. 2016;3(11):613-616.
8. Ministry of Health & Family Welfare: Guidelines for Clinical Management of Dengue Fever, Dengue
Hemorrhagic Fever and Dengue Shock Syndrome. New Delhi, India: Govt of India; 2008:2-14.
9. World Health Organization (WHO) and the Special Programme for Research and Training in
Tropical Diseases(TDR). Dengue: guidelines for diagnosis, treatment,prevention and control– New
Edition. Geneva, Switzerland. World Health Organisation. 2009:10-14.
10. Chavan SA , Padhiyar R, Kamtalwar S, Darole P. Study of clinical and laboratory predictors of in
hospital outcome in dengue fever in Mumbai city. IJRTSAT. 2016;19(2)304-308.
11. Kumar R, Shanker S, Ranjan R. A clinical and biochemical study of dengue fever in Kosi region of
Bihar, India. IJAM. 2017;4(4):964-967.
12. Narayanan M, Aravind MA, Thilothammal N, Prema R, Sargunam CS, Ramamurty N. Dengue Fever
Epidemic in Chennai - A Study of Clinical Profile and Outcome. Indian Pediatr. 2002;39:1027-1033.
13. Kalayanarooj S, Vaughn DW, Nimmannitya S et al. Early Clinical and Laboratory Indicators of
Acute Dengue Illness. IJID. 1997;176:313–21
14. Choudhary S, B.R Shivkumar , Adisesha S, Y.A. Manjunatha , M.M. Priyadarshini. Haematological
changes in dengue fever. njbms. 2003;III(4 ):289-293.
15. Ali N, Usman M, Syed N, Khurshid M. Haemorrhagic manifestations and utility of haematological
parameters in dengue fever tertiary care centre experience at Karachi. Scand J Infect Dis. 2007;
39:1025-8.
16. Gawoski JM, Ooi WW. Dengue fever mimicking plasma cell leukemia. Arch Pathol Lab Med. 2003;
127(8):1026-7.
17. Roberto da Justa Pires Neto, Saulo Lacerda Borges de Sá et al. Dengue infection in children and
adolescents in northeast Brazil. Rev. Soc. Bras. Med. Trop. 2013;46(6):765-768.
18.Lei HY, Yeh TM, Liu HS, Lin YS, Chen SH, Liu CC. Immuno pathogenesis of dengue virus infection. J
Biomed Sci. 2001;8:377-388.
19.Schexneider KI, Reddy EA. Thrombocytopenia in dengue fever. Curr Hematol Rep. 2005; 4:145-
148.
20.Bhaskar M, Moorthy S, Kumar NS, Arthur P. Dengue haemorrhagic fever among adults – An
Observational study in Chennai, south India. Indian J Med Res. 2010;132(6):738–740.
21.Seneviratne SL, Malavige GN, Silva HJ. Pathogenesis of liver involvement during dengue viral
infections. Trans R Soc Trop Med Hyg. 2006;100:608-614.
22.Silva EM, Conde JN, Allonso D, Nogueira ML, Mohana-Borges R. Mapping the Interactions of
Dengue Virus NS1 Protein with Human Liver Proteins Using a Yeast Two-Hybrid System:
Identification of C1q as an Interacting Partner. PLoS One. 2013;8:e57514.
23.Kularatne SA, Gawarammana IB, Kumarasiri PR. Epidemiology, clinical features, laboratory
investigations and early diagnosis of dengue fever in adults: a descriptive study in Sri Lanka.
Southeast Asian J Trop Med Public Health. 2005;36(3):686-92.
24. Babaliche P, Doshi D. Catching Dengue Early: Clinical Features and Laboratory Markers of Dengue
Virus Infection. J Assoc Physicians India. 2015;63(5):38-41.
Downloads
Published
17-12-2018
How to Cite
1.
Jethva VN, Thaker MV. A Study of Hematological Changes in Dengue Patients at A Tertiary Care Hospital, Bhavnagar, Gujarat. Ann of Pathol and Lab Med [Internet]. 2018 Dec. 17 [cited 2025 Feb. 4];5(12):A973-978. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/2163
Issue
Section
Original Article
License
Copyright (c) 2018 Vishva Narendrabhai Jethva, Mayuri Vasudevbhai Thaker
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
