Acute Myeloid Leukemia with complex hyperdiploid karyotype

A Case Report

Authors

  • Anurita Pais Dr
  • Shailesh Pande
  • Gauri Pradhan
  • Akshay Tharali
  • Smita Patil
  • Chaitali Parab

DOI:

https://doi.org/10.21276/apalm.2299

Keywords:

Acute myeloid leukemia, Hyperdiploidy, Complex Karyotype

Abstract

Hyperdiploidy in acute myeloid leukemia (AML) forms a subset of complex karyotype, which needs to be cytogenetically characterized so as to accurately determine its prognostic factor. The following study, involves the case of 54 year old female patient diagnosed with denovo acute myeloid leukemia by cytomorphological and immune-phenotype studies.

Cytogenetic analysis revealed a high hyperdiploid karyotype with a modal chromosome number ranging from 51~54 with the gain of chromosomes 8, 9, 11, 12 and 19 and also monosomy for chromosome 5. It also revealed other chromosomal abnormalities such as formation of derivative chromosome 10, isochromosome 21 and presence of a marker chromosome.

Present case reinforces the importance of cytogenetic categorization of an adverse-risk complex aberrant karyotype to stratify patients to individual optimized treatment strategies other than standard treatment in order to achieve good treatment outcome.

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Published

27-12-2018

How to Cite

1.
Pais A, Pande S, Pradhan G, Tharali A, Patil S, Parab C. Acute Myeloid Leukemia with complex hyperdiploid karyotype: A Case Report. Ann of Pathol and Lab Med [Internet]. 2018 Dec. 27 [cited 2024 Dec. 27];5(12):C185-189. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/2299

Issue

Vol. 5 No. 12 (2018)

Section

Case Report

License

Copyright (c) 2018 Anurita Pais, Shailesh Pande, Gauri Pradhan, Akshay Tharali, Smita Patil, Chaitali Parab

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