Gliosarcoma with Chondrosarcomatous Differentiation

A Case Report

Authors

  • Rajeshwari B Apollo Speciality Hospitals, Vanagaram, Chennai -600095. India
  • Salapathi Shanmugam Apollo Speciality Hospitals, Vanagaram, Chennai -600095. India
  • Sadiya Niamath Apollo Speciality Hospitals, Vanagaram, Chennai -600095. India
  • Mitra Ghosh Apollo Speciality Hospitals, Vanagaram, Chennai -600095. India
  • Siddhartha Ghosh Apollo Speciality Hospitals, Vanagaram, Chennai -600095. India

DOI:

https://doi.org/10.21276/apalm.2309

Keywords:

Chondrosarcoma, Glioblastoma, Gliosarcoma, PTEN, TERT

Abstract

Gliosarcoma (GS) is a variant of IDH wild type of glioblastoma (WHO grade IV). It is characterized by biphasic tissue pattern showing glial and mesenchymal components. The glial component is usually similar to glioblastoma and the sarcomatous component is usually spindle cell type.  Rarely the sarcomatous component can show additional lines of mesenchymal differentiation like cartilage, bone, smooth muscle, skeletal muscles etc. These tumours are more firm and discrete because of the high content of reticulin and collagen in the sarcomatous component. Originally these tumours were thought to arise from sarcomatous transformation of proliferating blood vessels or dedifferentiation of an advanced glioma. The recent studies show that both glial and sarcomatous component show identical mutations in p53, PTEN and TERT genes and suggest a monoclonal origin from a common stem cell. There is no significant difference in prognosis between glioblastoma and gliosarcoma. Here we report a case of gliosarcoma with chondrosarcomatous differentiation in a 52 year old gentleman.  The case is presented here for its rarity.

Author Biographies

Rajeshwari B, Apollo Speciality Hospitals, Vanagaram, Chennai -600095. India

Department of Histopathology

Salapathi Shanmugam, Apollo Speciality Hospitals, Vanagaram, Chennai -600095. India

Department of Histopathology

Sadiya Niamath, Apollo Speciality Hospitals, Vanagaram, Chennai -600095. India

Department of Histopathology

Mitra Ghosh, Apollo Speciality Hospitals, Vanagaram, Chennai -600095. India

Department of Histopathology

Siddhartha Ghosh, Apollo Speciality Hospitals, Vanagaram, Chennai -600095. India

Department of Neurosciences

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Published

15-02-2019

How to Cite

1.
B R, Shanmugam S, Niamath S, Ghosh M, Ghosh S. Gliosarcoma with Chondrosarcomatous Differentiation: A Case Report. Ann of Pathol and Lab Med [Internet]. 2019 Feb. 15 [cited 2024 Dec. 27];6(2):C5-8. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/2309

Issue

Vol. 6 No. 2 (2019)

Section

Case Report

License

Copyright (c) 2019 Rajeshwari B, Salapathi Shanmugam, Sadiya Niamath, Mitra Ghosh, Siddhartha Ghosh

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