Study of Histopathological Changes in Fibroadenoma of the Breast
DOI:
https://doi.org/10.21276/apalm.3194Keywords:
Breast cancer, Fibroadenoma, Fibrocystic changes, HyperplasiaAbstract
Background: Fibroadenoma of the breast is a relatively frequently occurring tumor. Although often considered a benign tumour, several reports describe a higher risk of subsequent breast carcinoma in patients diagnosed with fibroadenoma. Increased risk depends on presence of complex changes within fibroadenoma, presence of hyperplasia and positive family history for breast cancer.
Aims and Objectives: Our main aim was to study the histological variations within the fibroadenoma of the breast and also to identify those lesions with the possible risk of malignancy.
Methods: Descriptive study of three years. A total of 250 cases of fibroadenoma were studied. Slides were stained with Hematoxylin and Eosin (H & E) and were thoroughly reviewed. Slides were screened for proliferative epithelial changes, fibrocystic epithelial changes, stromal changes and various other changes such as foci of tubular adenoma and phyllodes tumour. Slides with invasive malignancies were excluded from the study.
Result: Apocrine change among fibrocystic changes was the commonest variation within the fibroadenoma. Complex fibroadenoma, moderate and atypical ductal hyperplasia was seen in older age groups.
Conclusion: Increased risk of breast cancer is seen patients with presence of hyperplasia and complex fibroadenoma of the breast. So exclusive study of histopathological changes in epithelial and stromal elements of fibroadenoma is required and are essential to be reported so as to alert the clinician for follow up of the patient. This will help in timely management to reduce morbidity and mortality.
References
Brogi E. Fibroepithelial neoplasms. In: Hoda SA, Brogi E, Koerner FC, Rosen PP. Rosen’s breast pathology. 4 th ed. Philadelphia, PA: Lippinkot Williams and Wilkins; 2014: 213-4.
Sklair-Levy M, Sella T, Alweiss T, Craciun I, Libson E, Mally B. Incidence and management of complex fibroadenomas. AJR Am J Roentgenol 2008; 190(1):214-8.
Dupont WD, Page DL, Parl FF, Vnencak-Jones CL, Plummer Jr WD, Rados MS et al. Long-term risk of breast cancer in women with fibroadenoma. N Engl J Med 1994 7; 331(1):10-5.
Deschenes L, Jacob S, Fabia J, Christen A. Beware of breast fibroadenomas in middle-aged women. Canadian Journal of Surgery 1985; 28(4):372-4.
Pick PW, Iossifides IA. Occurrence of breast carcinoma within a fibroadenoma. A review. Arch Pathol Lab Med 1984; 108(7):590-4.
Page DL, Anderson TJ, Rogers LW. Epithelial hyperplasia, and carcinoma in situ (CIS). In: Page DL, Anderson TJ. Diagnostic Histopathology of the Breast. Edinburgh, Scotland: Churchill Livingstone; 1987:120-192.
Holland R, Peterse JL, Millis RR, et al. Ductal carcinoma in situ: a proposal for a new classification. Semin Diagn Pathol. 1994; 11:167-80.
Brogi E. Fibroepithelial neoplasms. In: Hoda SA, Brogi E, Koerner FC, Rosen PP. Rosen’s breast pathology. 4th ed. Philadelphia, PA: Lippinkot Williams and Wilkins; 2014: 275-6.
Brogi E. Fibroepithelial neoplasms. In: Hoda SA, Brogi E, Koerner FC, Rosen PP. Rosen’s breast pathology. 4th ed. Philadelphia, PA: Lippinkot Williams and Wilkins; 2014:235-6.
Greenberg R, Skornick Y, Kaplan O. Management of Breast Fibroadenomas. JGIM. 1998; 13: 640-5.
Carty NJ, Ravichandran D, Carter C, Royle GT, Rubin C, Taylor I. Management of Fibroadenoma of the breast. Ann R Coll Surg Eng. 1995; 77:127-30.
Shabtai M, Saavedra-Malinger P, Shabtai EL, Rosin D, Kuriansky J, Ravid-Megido M et al. Fibroadenoma of the breast: analysis of associated pathological entities-a different risk marker in different age groups for concurrent breast cancer. Isr Med Assoc J 2001; 3(11):813-7.
Dent DM, Cant PJ. Fibroadenoma. World J Surgery. 1989; 13:706-10.
Kujiper A, Mommers EC, Van der Wall VD, Van Diest PJ. Histopathology of the fibroadenomas of the breast. Am J Clin Pathol 2001; 115:736-42.
Thakur B, Misra V. Clinicohistopathological features of Fibroadenoma Breast in patients less than 20 years of age and its comparison with elder patients. IOSR J Nurs Health Sci 2014; 3:67-71.
Tse G, Koo JS, Thike AA. Fibroepithelial tumours and hamartomas of the breast. In: Dilani Lokuhetty, Valerie A. White, Reiko Watanabe, Ian A. Cree. WHO Classification of Breast Tumours. 5th ed. Lyon: International Agency for Research on Cancer; 2019:175-6
McDivitt RW, Farrow JH, Stewart FW. Breast carcinoma arising in solitary fibroadenomas. Surg Gynecol Obstet. 1967; 125:572-76.
Azzopardil JG, Ahmed, Mills RR. Problems in Breast Pathology In: Bennigton JC. Major Problems. Edinburgh: WB Saunders Company Ltd, missed. 1979;325-328
Pharoah PDP, Day NE, Duffy S, et al. Family history and the risk of breast cancer: a systematic review and meta-analysis. Int J Cancer. 1997; 71:800-9.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Sneha P, Kavitha Yevoor
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).