Clinicopathological Study of Epithelial Lacrimal Gland Tumors at Tertiary Eye Hospital

  • Shaileshbhai Bhupatbhai Tadha Pathology Department, B.J. Medical College and Civil Hospital, Haripura, Asarwa, Ahmedabad, Gujarat, India
  • Viral Bhanvadia Pathology Department, B.J. Medical College and Civil Hospital, Haripura, Asarwa, Ahmedabad, Gujarat, India
  • Hansa Goswami Pathology Department, B.J. Medical College and Civil Hospital, Haripura, Asarwa, Ahmedabad, Gujarat, India
DOI: https://doi.org/10.21276/apalm.3320
Keywords: Lacrimal gland tumors, Orbit, Pleomorphic adenoma, Adenoid cystic carcinoma

Abstract

Background Lacrimal gland tumors are rare, constituting approximately 9% of all orbital lesions. Primary epithelial lacrimal gland tumors are histologically similar to those arising in the salivary glands. Pleomorphic adenoma and adenoid cystic carcinoma are the most common benign and malignant tumors, respectively. Material and Methods A retrospective study of 39 cases of lacrimal gland tumors over a period of 7 years was conducted. A detailed history of patients was taken with special attention to age, sex, macroscopic (gross examination), and microscopic features of the tissue. Microscopic examination was done using the standard H & E staining procedure. Results A total of 39 cases of lacrimal gland tumors were studied. Among them, there were 19 cases of pleomorphic adenoma, the most common benign tumor of the lacrimal gland, and 17 cases of adenoid cystic carcinoma, the most common malignant tumor. Conclusion The incidence of benign lesions was slightly lower than that of malignant tumors in this study. Benign tumors occurred in a younger age group compared to western studies. Among malignant tumors, adenoid cystic carcinomas were the most common.

References

Iwamoto T, Jakobiec FA. A comparative ultra-structural study of the normal lacrimal gland and its epithelial tumors. Hum Pathol. 1982;13:236-62.

Andreasen S, Esmaeli B, Holstein S, Mikkelsen L, Rasmussen P, Heegaard S. An update on tumors of the lacrimal gland. Asia Pac J Ophthalmol (Phila). 2017;6:159-72.

Shields JA, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1. Ophthalmology. 2004;111:997-1008.

Shields JA, Bakewell B, Augsburger JJ, et al. Classification and incidence of space-occupying lesions of the orbit. Arch Ophthalmol. 1984;102:1606-11.

Bagheri A, Ashtar-Nakhaie P, Aletaha M, Kheiri B, Veisi A. A survey on orbital space-occupying lesions during a twelve-year period from a referral center in Iran. J Ophthalmic Vis Res. 2023;18(2):202-11.

Johansen S, Heegaard S, Bøgeskov L, Prause JU. Orbital space-occupying lesions in Denmark 1974–1997. Acta Ophthalmol Scand. 2000;78:547-52.

Zeng J, Shi J, Li B, et al. Epithelial tumors of the lacrimal gland in the Chinese: a clinicopathologic study of 298 patients. Graefes Arch Clin Exp Ophthalmol. 2010;248:1345-9.

von Holstein SL, Therkildsen MH, Prause JU, et al. Lacrimal gland lesions in Denmark between 1974 and 2007. Acta Ophthalmol. 2013;91:349-54.

Szanto PA, Luna MA, Tortoledo ME, et al. Histologic grading of adenoid cystic carcinoma of the salivary glands. Cancer. 1984;54:1062-9.

Weis E, Rootman J, Joly TJ, et al. Epithelial lacrimal gland tumors: pathologic classification and current understanding. Arch Ophthalmol. 2009;127:1016-28.

Clarós P, Choffor-Nchinda E, Lopez-Fortuny M, Sobolewska AZ, Clarós A. Lacrimal gland pleomorphic adenoma: a review of 52 cases, 15-year experience. Acta Otolaryngol. 2019;139(1):100-4.

Shields CL, Shields JA, Eagle RC, et al. Clinicopathologic review of 142 lacrimal gland lesions. Ophthalmology. 1989;96:431-5.

Sen S, Mahindrakar A, Betharia S, et al. Pleomorphic adenomas of the lacrimal gland—a clinicopathologic analysis. Clin Experiment Ophthalmol. 2004;32:523-5.

Lee DA, Campbell RJ, Waller RR, et al. A clinicopathologic study of primary adenoid cystic carcinoma of the lacrimal gland. Ophthalmology. 1985;92:128-34.

Chawla B, Kashyap S, Sen S, Bajaj MS, Pushker N, Gupta K, et al. Clinicopathologic review of epithelial tumors of the lacrimal gland. Ophthalmic Plast Reconstr Surg. 2013;29:440-5.

Henderson JW, Campbell R, Farrow G, et al. Orbital tumors. 3rd ed. New York: Raven Press; 1994.

McLean IW, Burnier MN, Zimmerman LE, et al. Tumors of the lacrimal gland and sac. In: McLean IW, Burnier MN, Zimmerman LE, et al, editors. Tumors of the eye and ocular adnexa. Washington: Armed Forces Institute of Pathology; 1994. p. 215-7. (Atlas of tumor pathology; 3rd series, part 12).

Wright JE, Rose GE, Garner A. Primary malignant neoplasms of the lacrimal gland. Br J Ophthalmol. 1992;76:401-7.

Published
26-05-2024
Issue
Vol 11 No 6 (2024)
Section
Original Article

Copyright (c) 2024 Shaileshbhai Bhupatbhai Tadha, Viral Bhanvadia, Hansa Goswami

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