Clinicopathological Study of Epithelial Lacrimal Gland Tumors at Tertiary Eye Hospital
DOI:
https://doi.org/10.21276/apalm.3320Keywords:
Lacrimal gland tumors, Orbit, Pleomorphic adenoma, Adenoid cystic carcinomaAbstract
Background
Lacrimal gland tumors are rare, constituting approximately 9% of all orbital lesions. Primary epithelial lacrimal gland tumors are histologically similar to those arising in the salivary glands. Pleomorphic adenoma and adenoid cystic carcinoma are the most common benign and malignant tumors, respectively.
Material and Methods
A retrospective study of 39 cases of lacrimal gland tumors over a period of 7 years was conducted. A detailed history of patients was taken with special attention to age, sex, macroscopic (gross examination), and microscopic features of the tissue. Microscopic examination was done using the standard H & E staining procedure.
Results
A total of 39 cases of lacrimal gland tumors were studied. Among them, there were 19 cases of pleomorphic adenoma, the most common benign tumor of the lacrimal gland, and 17 cases of adenoid cystic carcinoma, the most common malignant tumor.
Conclusion
The incidence of benign lesions was slightly lower than that of malignant tumors in this study. Benign tumors occurred in a younger age group compared to western studies. Among malignant tumors, adenoid cystic carcinomas were the most common.
References
Iwamoto T, Jakobiec FA. A comparative ultra-structural study of the normal lacrimal gland and its epithelial tumors. Hum Pathol. 1982;13:236-62.
Andreasen S, Esmaeli B, Holstein S, Mikkelsen L, Rasmussen P, Heegaard S. An update on tumors of the lacrimal gland. Asia Pac J Ophthalmol (Phila). 2017;6:159-72.
Shields JA, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1. Ophthalmology. 2004;111:997-1008.
Shields JA, Bakewell B, Augsburger JJ, et al. Classification and incidence of space-occupying lesions of the orbit. Arch Ophthalmol. 1984;102:1606-11.
Bagheri A, Ashtar-Nakhaie P, Aletaha M, Kheiri B, Veisi A. A survey on orbital space-occupying lesions during a twelve-year period from a referral center in Iran. J Ophthalmic Vis Res. 2023;18(2):202-11.
Johansen S, Heegaard S, Bøgeskov L, Prause JU. Orbital space-occupying lesions in Denmark 1974–1997. Acta Ophthalmol Scand. 2000;78:547-52.
Zeng J, Shi J, Li B, et al. Epithelial tumors of the lacrimal gland in the Chinese: a clinicopathologic study of 298 patients. Graefes Arch Clin Exp Ophthalmol. 2010;248:1345-9.
von Holstein SL, Therkildsen MH, Prause JU, et al. Lacrimal gland lesions in Denmark between 1974 and 2007. Acta Ophthalmol. 2013;91:349-54.
Szanto PA, Luna MA, Tortoledo ME, et al. Histologic grading of adenoid cystic carcinoma of the salivary glands. Cancer. 1984;54:1062-9.
Weis E, Rootman J, Joly TJ, et al. Epithelial lacrimal gland tumors: pathologic classification and current understanding. Arch Ophthalmol. 2009;127:1016-28.
Clarós P, Choffor-Nchinda E, Lopez-Fortuny M, Sobolewska AZ, Clarós A. Lacrimal gland pleomorphic adenoma: a review of 52 cases, 15-year experience. Acta Otolaryngol. 2019;139(1):100-4.
Shields CL, Shields JA, Eagle RC, et al. Clinicopathologic review of 142 lacrimal gland lesions. Ophthalmology. 1989;96:431-5.
Sen S, Mahindrakar A, Betharia S, et al. Pleomorphic adenomas of the lacrimal gland—a clinicopathologic analysis. Clin Experiment Ophthalmol. 2004;32:523-5.
Lee DA, Campbell RJ, Waller RR, et al. A clinicopathologic study of primary adenoid cystic carcinoma of the lacrimal gland. Ophthalmology. 1985;92:128-34.
Chawla B, Kashyap S, Sen S, Bajaj MS, Pushker N, Gupta K, et al. Clinicopathologic review of epithelial tumors of the lacrimal gland. Ophthalmic Plast Reconstr Surg. 2013;29:440-5.
Henderson JW, Campbell R, Farrow G, et al. Orbital tumors. 3rd ed. New York: Raven Press; 1994.
McLean IW, Burnier MN, Zimmerman LE, et al. Tumors of the lacrimal gland and sac. In: McLean IW, Burnier MN, Zimmerman LE, et al, editors. Tumors of the eye and ocular adnexa. Washington: Armed Forces Institute of Pathology; 1994. p. 215-7. (Atlas of tumor pathology; 3rd series, part 12).
Wright JE, Rose GE, Garner A. Primary malignant neoplasms of the lacrimal gland. Br J Ophthalmol. 1992;76:401-7.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Shaileshbhai Bhupatbhai Tadha, Viral Bhanvadia, Hansa Goswami
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
