Mean Platelet Volume In Diabetes Mellitus Type II
Keywords:
Mean Platelet Volume, Diabetes Mellitus, HbA1c.
Abstract
Background: Diabetes Mellitus (DM) is a metabolic disorder and a major health problem because of its high prevalence and morbidity. Platelets have a key role in development of its thrombogenic complications. Platelet size is considered as a marker and determinant of platelet function with younger, larger platelets exhibiting more reactivity. This study was carried out to compare Mean Platelet Volume (MPV) in subjects with diabetes and non diabetic controls.Method: Total 211 subjects, 105 diabetics and 106 nondiabetic controls were included. MPV, platelet count, blood glucose levels, lipid profile and HbA1c levels were measured and data analyzed by independent “t” test.Result: Mean MPV was significantly higher in the diabetic group compared to the controls (9.94 ± 1.07 fl versus 9.36 ± 0.96 fl; p=.00003). Mean BMI, cholesterol and triglycerides were also significantly higher in the diabetic group. Within the diabetic group, mean MPV, cholesterol and triglycerides were significantly higher in subjects with HbA1c ≥ 6.5% (10.30±0.95fl vs 9.82±1.08fl, p=.03; 206.28±37.17 mg/dl vs 185.07±41.91 mg/dl, p=.026; 176.96 ± 88.54 mg/dl vs 133.19 ± 46.30 mg/dl, p=.002 respectively).Conclusion: High MPV in diabetics may indicate platelet hyperactivity, which may contribute to the vascular complications of type II DM. Thus MPV can be used as a simple, costeffective parameter to assess the probability of developing vascular complications in diabetes.References
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30. Kadić D, Hasić S, Spahić E. Mean platelet volume predicts the glycemic control deterioration in diabetes mellitus type 2 patients. Medicinski Glasnik 2016; 13(1): 1-7.
31. Altamer E, Vendemisle G, Chicco D; Increased lipid peroxidation in Type-II poorly control Diabetic patients. Diabetes Etab., 1991; 18(4):264-671.
32. Jain AP, Gupta DP; Study of blood lipids in Diabetics without any manifest vascular complications. J Dia Asso Ind., 1980; 20: 29-34.
33. Suckling KE., Brian J; Animal Models of Human lipid Metabolism. Prog Lipid Res.1993; 32(1): 124–124.
34. Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000; 321: 405−12.
35. Michelson AD; Methods for the measurement of platelet function. Am J Cardiol., 2009;103(3Suppl.): 20A–26A
36. Nicholson NS, Panzer-Knodle SG, Haas NF, Taite BB, Szalony JA, Page JD et al.; Assessment of platelet function assays. Am Heart J., 1998;135(5 Pt 2 Su):S170–S178
2. UK Prospective Diabetes Study Group (UKPDS): Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998; 352:837 –853.
3. Vizioli L, Muscari S, Muscari A: The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract. 2009; 63:1509–1515.
4. Tschoepe D, Roesen P, Schwippert B, Gries FA. “Platelets in diabetes: the role in the hemostatic regulation in atherosclerosis,” Seminars in Thrombosis and Hemostasis.1993; 19: 122–128.
5. Khuwaja AK, Rafique G, White F, Azam SI. Macrovascular complications and their associated factors among persons with type 2 diabetes in Karachi, Pakistan--a multi-center study. J Pak Med Assoc. 2004; 54:60-6.
6. Tufano A, Cimino E, Di Minno M.N.D, et al. “Diabetes Mellitus and Cardiovascular Prevention: The Role and the Limitations of Currently Available Antiplatelet Drugs.” International Journal of Vascular Medicine. vol. 2011; Article ID 250518: 1-5.
7. King H, Aubert RE, Herma WH. Global burden of diabetes,1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 1998; 21:1414-31.
8. Hekimsoy Z, Payzin B, Ornek T, Kandoğan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004; 18:173-6.
9. Zuberi BF, Akhtar N, Afsar S. Comparison of mean platelet volume in patients with diabetes mellitus, impaired fasting glucose and non-dia¬betic subjects. Singapore Med J 2008; 49: 114-116
10. Kodiatte TA, Manikyam UK, Rao SB, Jagadish TM, Reddy M, Lingaiah HK and Lakshmaiah V. Mean platelet volume in Type 2 diabetes mel¬litus. J Lab Physicians 2012; 4: 5-9.
11. Ulutas KT, Dokuyucu R, Sefil F, Yengil E et al. Evaluation of mean platelet volume in patients with type 2 diabetes mellitus and blood glucose regulation: a marker for atherosclerosis?. Int J Clin Exp Med 2014;7(4):955-961
12. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011; 17:47-58.
13. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996; 7:157-61.
14. Randriamboavonjy V, Fleming I. Platelet function and signal¬ing in diabetes mellitus. Curr Vasc Pharmacol 2012; 10:532-8.
15. Jokl R, A. CJ. Arterial thrombosis and atherosclerosis in diabe¬tes. . Diabetes Metab Rev 1997; 5:1-15.
16. Dindar S, Cinemre H, Sengul E, Annakkaya AN. Mean Platelet volume is associated with glycemic control and retinopathy in patients with type 2 diabetes mellitus.West Indian Med J 2013; 62(6): 519-523.
17. Demirtunc R, Duman D, Basar M, Bilgi M, Teomete M, Garip T. The relationship between glycemic con¬trol and platelet activity in type 2 diabetes mellitus. J Diabetes Complications 2009; 23:89-94.
18. Ozder A, Eker HH. Investigation of mean platelet volume in patients with type 2 diabetes mellitus and in subjects with impaired fasting glucose: a cost-effective tool in primary health care? Int J Clin Exp Med 2014; 7:2292-7.
19. Sharpe PC, Trinick T. Mean platelet volume in diabetes mellitus. Q J Med 1993; 86: 739−42.
20. Cakir L, Aktas G, Enginyurt O, Cakir SA. Mean Platelet volume increases in type 2 diabetes mellitus independent of HbA1c level. Acta Medica Mediterranea 2014; 30: 425-428.
21. Unubol M, Ayhan M, Guney E. The relationship between mean platelet volume with microalbuminuria and glycemic control in patients with type II diabetes mellitus. Platelets 2012; 23: 475–80.
22. Yenigün EC, Okyay GU, Pirpir A, Hondur A, Yıldırım IS. Increased mean platelet volume in type 2 diabetes mellitus. Dicle Medical Journal. 2014; 41 (1): 17-22
23. Kim JH, Kang SB, Kang JI, Kim JW, Kim SY, Bae HY. The rela¬tionship between mean platelet volume and fasting plasma glucose differs with glucose tolerance status in a Korean gener¬al population: gender differences. Platelets 2013; 24: 469-73.
24. Tschöpe D, Langer E, Schauseil S. Increased platelet vol¬ume- sign of impaired thrombopoiesis in diabetes mellitus. Klin Wochenschr 1989; 67: 253-259.
25. Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010; 8: 148-156.
26. Jones R L, Paradise C, Peterson C M. Platelet survival in patients with diabetes mellitus. Diabetes 1981;30:486-489.
27. Jabeen F, Rizvi HA, Aziz F, Akhtar Y. Effect of Glycemic Control on Lipid Profile, Platelet Indices and Antioxidant Enzymes (Catalase and Superoxide dismutase) Activities in Type 2 Diabetics. International Journal of Advanced Research 2013; 1: 207-215.
28. Vijaya C, Shetty A, Parikshith. Comparative Study of Significance of Lipid Profile, Platelet Count and MPV-Diabetics and Non-Diabetics. Sch. J. App. Med. Sci. 2014; 2(5B):1584-1588
29. Alhadas KR, Santos SN, S. Freitas MM, Viana SMAA, Ribeiro LC, Mônica B. Costa MB. Are platelet indices useful in the evaluation of type 2 diabetic patients? Bras Patol Med Lab, April 2016 ;52(2): 96-102.
30. Kadić D, Hasić S, Spahić E. Mean platelet volume predicts the glycemic control deterioration in diabetes mellitus type 2 patients. Medicinski Glasnik 2016; 13(1): 1-7.
31. Altamer E, Vendemisle G, Chicco D; Increased lipid peroxidation in Type-II poorly control Diabetic patients. Diabetes Etab., 1991; 18(4):264-671.
32. Jain AP, Gupta DP; Study of blood lipids in Diabetics without any manifest vascular complications. J Dia Asso Ind., 1980; 20: 29-34.
33. Suckling KE., Brian J; Animal Models of Human lipid Metabolism. Prog Lipid Res.1993; 32(1): 124–124.
34. Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000; 321: 405−12.
35. Michelson AD; Methods for the measurement of platelet function. Am J Cardiol., 2009;103(3Suppl.): 20A–26A
36. Nicholson NS, Panzer-Knodle SG, Haas NF, Taite BB, Szalony JA, Page JD et al.; Assessment of platelet function assays. Am Heart J., 1998;135(5 Pt 2 Su):S170–S178
Published
15-12-2016
Section
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