Inflammatory Myofibroblastic Tumor Of Urinary Bladder
Keywords:
ALK 1 immunostain, Inflammatory myofibroblastic tumor, spindle myoepithelial cell proliferation.Abstract
Inflammatory myofibroblastic tumor (IMT) is an uncommon benign tumor of intermediate neoplastic potential, characterised by spindle cell proliferation with characteristic fibroinflammatory and pseudosarcomatous appearance. A subset of IMT with histologic atypia and/or clinical aggressiveness is also known. IMTs occur in the mesentery, omentum, retroperitoneum, pelvis, and abdominal soft tissues. However, the occurrence of IMT in urinary bladder is unusual. IMT exhibits morphologic and immunophenotypic overlap with malignant spindle cell tumors of the urinary bladder and is diagnostically challenging. In the case presented, ALK-1 and SMA immunostains helped to identify IMT. Anaplastic Lymphoma Kinase (ALK) gene translocation or ALK gene expression can further confirm IMT. Complete surgical excision with follow-up is the treatment of choice for IMT.
DOI: 10.21276/APALM.1129
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