Inflammatory Myofibroblastic Tumor Of Urinary Bladder
Keywords:
ALK 1 immunostain, Inflammatory myofibroblastic tumor, spindle myoepithelial cell proliferation.Abstract
Inflammatory  myofibroblastic  tumor  (IMT)  is  an  uncommon  benign  tumor  of  intermediate  neoplastic  potential,  characterised   by spindle  cell  proliferation  with  characteristic  fibroinflammatory  and  pseudosarcomatous  appearance.  A  subset of  IMT  with  histologic  atypia  and/or  clinical  aggressiveness  is also  known. IMTs occur in the mesentery, omentum, retroperitoneum, pelvis, and abdominal soft tissues. However, the occurrence of IMT in urinary bladder is unusual. IMT exhibits morphologic and immunophenotypic overlap with malignant spindle cell tumors of the urinary bladder and is diagnostically challenging. In the case presented, ALK-1 and SMA immunostains helped to identify IMT. Anaplastic  Lymphoma  Kinase (ALK)  gene  translocation or ALK gene expression can further confirm IMT. Complete surgical  excision  with  follow-up  is  the  treatment  of  choice  for  IMT.Â
DOI:Â 10.21276/APALM.1129
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