Synchronous Primary Ovarian Mucinous Carcinoma and Endometrioid Endometrial Carcinoma : A rare case report.
Keywords:
synchronous, ovarian tumour, endometrial adenocarcinoma, immunohistochemistry
Abstract
Introduction: Synchronous tumours of female genital tract are a rare . The most common organs involved are ovary and endometrium. Endometrioid carcinoma is the most common malignancy detected in majority of cases . Synchronous cancers with dissimilar histology are a very rare phenomenon . We report a case of 51 year old lady with synchronous primary mucinous carcinoma of ovary and primary endometrioid endometrial carcinoma .Case report: a 51 year old lady presented with post menopausal bleeding and foul smelling vaginal discharge of 1 month duration . Her CA125 was elevated. Magnetic resonance imaging showed increased endometrial thickness and a12.5x10x9.3cm mass in the fundus of uterus suggestive of a leiomyoma along with and a 13.8x11.5x11cm mass in the left adnexa. Endometrial aspiration done showed Complex Hyperplasia with Atypia. Total abdominal hysterctomy and bilateral salphingoophorectomy along with lymphnode sampling was performed . The adnexal mass was pT1a pN0 cM0 grade 2 invasive mucinous carcinoma. The endometrial lesion was pT1b pN0 cM0 FIGO grade 2 endometrioid endometrial adenocarcinoma.Conclusion: Synchronous ovarian tumours of dissimilar histology is extremely rare and there are only a few reports of ovarian mucinous carcinoma with endometrioid endometrial carcinoma. DOI: 10.21276/APALM.1295References
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7. Liu Y, Li J, Jin H, Lu Y, Lu X. Clinicopathological characteristics of patients with synchronous primary endometrial and ovarian cancers: A review of 43 cases. Oncology letters. 2013 Jan 1;5(1):267-70.
8. van Niekerk CC, Bulten J, Vooijs GP, Verbeek AL. The association between primary endometrioid carcinoma of the ovary and synchronous malignancy of the endometrium. Obstetrics and gynecology international. 2009 Dec 15;2010.
9. Szmich SD, Czernek U, Krakowska M, Frąckowiak M, Zięba A, Czyżykowski R, Kulejewska D, Potemski P. Synchronous primary ovarian and endometrial cancers: a series of cases and a review of literature. PrzMenopauzalny. 2014 Mar;13:64-9.
10. Soliman PT, Slomovitz BM, Broaddus RR, Sun CC, Oh JC, Eifel PJ, Gershenson DM, Lu KH. Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases. Gynecologic oncology. 2004 Aug 31;94(2):456-62.
11. Signorelli M, Fruscio R, Lissoni AA, Pirovano C, Perego P, Mangioni C. Synchronous early‐stage endometrial and ovarian cancer. International Journal of Gynecology& Obstetrics. 2008 Jul 1;102(1):34-8.
2. Eisner RF, Nieberg RK, Berek JS. Synchronous primary neoplasms of the female reproductive tract. Gynecologic oncology. 1989 Jun 1;33(3):335-9.
3. Zaino R, Whitney C, Brady MF, DeGeest K, Burger RA, Buller RE. Simultaneously detected endometrial and ovarian carcinomas—a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecologic oncology. 2001 Nov 1;83(2):355-62.
4. Scully REYR, Clement PB: Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube, and Broad Ligament: Atlas of Tumor Pathology. Bethesda, MD, Armed Forces Institute of Pathology, 1998
5. CHIANG YC, CHEN CA, HUANG CY, HSIEH CY, CHENG WF. Synchronous primary cancers of the endometrium and ovary. International Journal of Gynecological Cancer. 2008 Jan 1;18(1):159-64.
6. Lim YK, Padma R, Foo L, Chia YN, Yam P, Chia J, Khoo-Tan HS, Yap SP, Yeo R. Survival outcome of women with synchronous cancers of endometrium and ovary: a 10 year retrospective cohort study. Journal of gynecologic oncology. 2011 Dec 31;22(4):239-43.
7. Liu Y, Li J, Jin H, Lu Y, Lu X. Clinicopathological characteristics of patients with synchronous primary endometrial and ovarian cancers: A review of 43 cases. Oncology letters. 2013 Jan 1;5(1):267-70.
8. van Niekerk CC, Bulten J, Vooijs GP, Verbeek AL. The association between primary endometrioid carcinoma of the ovary and synchronous malignancy of the endometrium. Obstetrics and gynecology international. 2009 Dec 15;2010.
9. Szmich SD, Czernek U, Krakowska M, Frąckowiak M, Zięba A, Czyżykowski R, Kulejewska D, Potemski P. Synchronous primary ovarian and endometrial cancers: a series of cases and a review of literature. PrzMenopauzalny. 2014 Mar;13:64-9.
10. Soliman PT, Slomovitz BM, Broaddus RR, Sun CC, Oh JC, Eifel PJ, Gershenson DM, Lu KH. Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases. Gynecologic oncology. 2004 Aug 31;94(2):456-62.
11. Signorelli M, Fruscio R, Lissoni AA, Pirovano C, Perego P, Mangioni C. Synchronous early‐stage endometrial and ovarian cancer. International Journal of Gynecology& Obstetrics. 2008 Jul 1;102(1):34-8.
Published
26-08-2017
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Section
Case Report
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