A rare case of primary leiomyosarcoma of thyroid in a young adult with literature review
Keywords:
Thyroid gland, thyroid neoplasms, primary leiomyosarcoma of thyroid, young maleAbstract
Primary leiomyosarcoma of the thyroid gland (PLT) is an extremely rare neoplasm and still rarer is its occurrence in younger age group. It is one of the most aggressive malignancies with high metastasizing potential. They can be difficult to diagnose on histopathology and can mimic anaplastic or medullary thyroid carcinoma. Only 22 cases of PLT have been reported in the literature and the youngest patient was a 39 years old male. However we report a case of PLT in a 23 years male, being the youngest patient reported till date (23rd in series). He presented with progressively increasing anterior neck swelling since two months and underwent total thyroidectomy. Histopathology and immunohistochemistry showed features suggestive of leiomyosarcoma of the thyroid gland. Two months later, the tumour recurred at subglottis for which he underwent total laryngo-pharyngectomy followed by radiotherapy. Patient was on regular follow up for one and half year with no recurrence and lost to follow up later.
References
2. Bertelli AA, Massarollo LC, Volpi EM, Ueda RY, Barreto E. Thyroid gland primary leiomyosarcoma. Arq Bras Endocrinol Metabol 2010; 54(3):326-30.
3. Hedinger C, Williams ED, Sobin LH. Histologic typing of thyroid tumors. In: World Health Organization International histologic classiï¬cation of tumors. 2nd ed. Berlin: Springer; 1988. pp. 13–5.
4. Amal B, El Fatemi H, Souaf I, Moumna K, Affaf A. A rare primary tumor of the thyroid gland: report a new case of leiomyosarcoma and literature review. DiagnPathol 2013; 27;8:36.
5. Mansouri H, Gaye M, Errihani H, Kettani F, Gueddari BE. Leiomyosarcoma of the thyroid gland. ActaOtolaryngol 2008; 128(3):335-6.
6. Ege B, LeventoÄŸlu S. Primary leiomyosarcoma of the thyroid. J Korean Surg Soc 2013; 85(1):43-6.
7. Tanboon J, Keskool P. Leiomyosarcoma: a rare tumor of the thyroid. EndocrPathol 2013; 24(3):136-43.
8. Mouaqit O, Belkacem Z, Ifrine L, Mohsine R, Belkouchi A. A rare tumor of the thyroid gland: report on one case of leiomyosarcoma and review of literature. Updates Surg 2014; 66(2):165-7.
9. Thompson LD, Wenig BM, Adair CF, Shmookler BM, Heffess CS: Primary smooth muscle tumors of the thyroid gland. Cancer 1997; 79: 579 87.
Downloads
Additional Files
Published
How to Cite
Issue
Section
License
Copyright (c) 2016 Rushabh Jitendra Shah, Rachana Amit Chaturvedi, Leena Pravin Naik
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).