Childhood Onset Systemic Lupus Erythematosus with Direct Coombs Test Positive in the Absence of Hemolytic Anemia – A Rare Case Report
DOI:
https://doi.org/10.21276/apalm.3038Keywords:
Systemic Lupus Erythematosus, Direct Coombs test, hemolytic anemiaAbstract
Systemic Lupus Erythematosus being a chronic autoimmune multisystem inflammatory disease, affects predominantly women of reproductive age group. Childhood – Onset Systemic Lupus Erythematosus is a rare disease with an incidence of 10% - 20%. Positive direct Coombs test in the absence of hemolytic anemia indicates high disease activity and severe renal damage. Herein we report a case of 11-year-old female child diagnosed as Systemic Lupus Erythematosus with positive direct Coombs test in absence of hemolytic anemia which is very rare.
References
Manson, J.J., Rahman, A. Systemic lupus erythematosus. Orphanet J Rare Dis 2006 Mar 27;1: 6.
Harry O, Yasin S, Brunner H. Childhood-Onset Systemic Lupus Erythematosus: A Review and Update. J Pediatr. May; 196: 22-30. e2.
Hanaoka H, Iida H, Kiyokawa T, Takakuwa Y, Kawahata K. A positive direct Coombs' test in the absence of hemolytic anemia predicts high disease activity and poor renal response in systemic lupus erythematosus. Lupus. 2018 Dec; 27(14) :2274-78.
Master Sankar Raj V. An unusual presentation of lupus in a pediatric patient. August 2013.Case reports in Paediatrics 2013(1): 180208;
Ferraria N, Rocha S, Fernandes VS, Correia T, Gonçalves E. Juvenile systemic lupus erythematosus with primary neuropsychiatric presentation. BMJ Case Rep. 2013Jan 25.
Amit Kumar, Pradeep Kumar, Masuma P. Bhengra, Prabhat Kumar, Syam Sundar Chaudhary, Childhood-onset systemic lupus erythematosus – a case report, J. Pak. Assoc. Dermatol. 2016;26(1): 76- 79
Tucker LB, Menon S, Schaller JG, Isenberg DA. Adult- and childhood-onset systemic lupus erythematosus: a comparison of onset, clinical features, serology, and outcome. Br J Rheumatol. 1995: Sep; 34(9): 866-72.
Mongan ES, Leddy JP, Atwater EC, Barnett EV (1967) Direct antiglobulin (Coombs) reactions in patients with connective tissue diseases. Arthritis Rheum 1967 Dec; 10(6): 502- 8
Inada Y, Kamiyama M, Kanemitsu T, Clark WS, Asai Y. Relationships between C3b receptor (CR1) activity of erythrocytes and positive Coombs' tests. Ann Rheum Dis. 1986 May;45(5):367-72.
Petri M, Orbai AM, Alarcón GS, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012; Aug 64(8): 2677-86.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Vani Sreekumar, Mangaiyarkarasi .
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
