Anaplastic Meningioma: A Rare Case Report
DOI:
https://doi.org/10.21276/apalm.3471Keywords:
Anaplastic meningioma, Meningioma, ImmunohistochemicalAbstract
Meningiomas are tumors arising from the leptomeninges. The malignant counterpart of them is known as anaplastic meningioma, which are WHO grade 3 tumors. Histopathology and immunohistochemistry are confirmatory for subtyping of meningioma. We present a case of a 45-year-old male who presented with usual symptoms of headache and projectile vomiting. After surgery, the clinical diagnosis of meningioma was made, and the tissue was sent to the pathology department. Definitive diagnosis revealed a high-grade spindle cell neoplasm disposed in sheets with markedly elevated and atypical mitoses. Large cells with eccentric cytoplasm were also seen. IHC was positive for vimentin and EMA and negative for GFAP. A final diagnosis of anaplastic meningioma was made. During follow-up, the patient also received adjuvant radiotherapy post-surgery. Anaplastic meningioma is very rare and generally known to have a poorer prognosis. The extent of resection is associated with prognosis of patients with all WHO grades of meningioma.
References
1. Ostrom QT, Cioffi G, Gittleman H, Patil N, Waite K, Kruchko C, et al. CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2012–2016. Neuro Oncol. 2019;21(Suppl 5):v1–v100.
2. Hanft S, Canoll P, Bruce JN. A review of malignant meningiomas: Diagnosis, characteristics, and treatment. J Neurooncol. 2010;99(3):433–43.
3. Champeaux C, Wilson E, Brandner S, Shieff C, Thorne L. World Health Organization grade III meningiomas: A retrospective study for outcome and prognostic factors assessment. Br J Neurosurg. 2015;29(5):693–8.
4. Nishida N, Kanchiku T, Imajo Y, Suzuki H, Yoshida Y, Kato Y, et al. A case of an anaplastic meningioma metastasizing to the mediastinal lymph nodes. J Spinal Cord Med. 2016;39(4):484–92.
5. Najjar MW, Abdul Halim NH, Sukhon FR, Youssef B, Assi HI. Anaplastic meningioma presenting as a left parietal mass: A case report. Am J Case Rep. 2017;18:1166–70.
6. Hanft S, Canoll P, Bruce JN. A review of malignant meningiomas: Diagnosis, characteristics, and treatment. J Neurooncol. 2010;99(3):433–43.
7. Cimino PJ. Malignant progression to anaplastic meningioma: Neuropathology, molecular pathology, and experimental models. Exp Mol Pathol. 2015;99(2):354–9.
8. Buhl R, Nabavi A, Wolff S, Hugo HH, Alfke K, Jansen O, et al. MR spectroscopy in patients with intracranial meningiomas. Neurol Res. 2007;29(1):43–6.
9. Zeng L, Liang P, Jiao J, Chen J, Lei T. Will an asymptomatic meningioma grow or not grow? A meta-analysis. J Neurol Surg A Cent Eur Neurosurg. 2015;76(5):341–7.
10. Maggio I, Franceschi E, Tosoni A, Di Nunno V, Gatto L, Lodi R, et al. Meningioma: Not always a benign tumor. A review of advances in the treatment of meningiomas. CNS Oncol. 2021;10(1):CNS72.
11. Huang RY, Bi WL, Weller M, Kaley T, Blakeley J, Dunn I, et al. Proposed response assessment and endpoints for meningioma clinical trials: Report from the Response Assessment in Neuro-Oncology Working Group. Neuro Oncol. 2019;21(1):26–36.
12. Mao C, Li J, Rao L. Anaplastic meningioma: A case report and literature review. Int J Clin Exp Med. 2019;12(7):9418–24.
13. Di Nunno V, Giannini C, Asioli S, Conti A, Furtner J, Balestrini D, et al. Diagnostic and therapeutic strategy in anaplastic (malignant) meningioma, CNS WHO grade 3. Cancers (Basel). 2022;14(19):4689.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Sumiti Gupta, Ankush, Vibhav Goel, Mahak Dahiya, Sunita Singh
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
