Histopathology of Ovarian Collision Tumor: A Rare Case Report

Authors

  • Pinku Bordoloi Department of Pathology, Gauhati Medical College & Hospital, Guwahati, Assam, India
  • Junu Devi Department of Pathology, Gauhati Medical College & Hospital, Guwahati, Assam, India
  • Ena Dowerah Department of Pathology, Gauhati Medical College & Hospital, Guwahati, Assam, India

DOI:

https://doi.org/10.21276/apalm.3478

Keywords:

Collision tumour, Mucinous cyst, Serous cystadenoma, Teratoma

Abstract

Collision tumour is defined as the coexistence of two or more adjacent but histologically distinct tumours without histological mixture in the same tissue or organ. Collision tumours involving ovaries are extremely rare. Although they have been reported in various organs, ovarian collision tumours are very rare. An ovarian tumour with a cystadenoma or cystadenocarcinoma, typically of the mucinous type, is the most commonly encountered combination. Each component of the collision tumour occurs coincidentally, and no connection is found between the tumours. Our case is a collision tumour of the ovary composed of serous cyst, mucinous cystadenoma, and mature cystic teratoma (dermoid cyst). The aim is to present a rare case.

Histopathological processing was done, and Hematoxylin (H) and Eosin (E) stain was used for staining. Though very rare, it is necessary to be aware of collision tumours and the combination of tumours that exist, as the appropriate treatment can then be given to the patient. The most common form of ovarian collision tumour in the literature is the combination with teratoma. Histological recognition of such neoplasms is important, allowing appropriate treatment to be offered to patients according to the individual biological characteristics of each of the components.

References

1. Alayed AM, Almawi AS, Alghamdi EG, Alfaleh HS, Kadasah NS, Alayed AM, Almawi AS, Alfaleh HS. Ovarian collision tumor, massive mucinous cystadenoma, and benign mature cystic teratoma. Cureus. 2021 Jul 6;13(7).

2. Borges A, Loddo A, Martins A, Peiretti M, Fanni D, Djokovic D. Collision tumors in ovary: case series and literature review. J Surg Oncol. 2019;2:2-10.

3. Caroli E, Salvati M, Rocchi G, Frati A, Cimatti M, Raco A. Post-traumatic intracranial meningiomas. Tumori. 2003 Jan;89(1):6-8.

4. Louis DN, Ramesh V, Gusella JF. Neuropathology and molecular genetic of neurofibromatosis 2 and related tumours. Brain Pathol. 1995;15(2):163-72.

5. Nirenberg A, Östör AG, Quinn MA. Collision tumor: serous adenocarcinoma and steroid cell tumor of the ovary. Pathology. 1992 Jan;24(2):60-2.

6. Cohen A, Geller SA, Horowitz I, Toth LS, Werther JL. Experimental models for gastric leiomyosarcoma. The effects of N-Methyl-N′-Nitro-N-Nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate. Cancer. 1984 Mar 1;53(5):1088-92.

7. Brahmania M, Kanthan CS, Kanthan R. Collision tumor of the colon–colonic adenocarcinoma and ovarian granulosa cell tumor. World J Surg Oncol. 2007 Dec;5:1-5.

8. Hemalatha A, Ashok K, Anoosha K, Amita K, Raghuveer C. A morphologically distinct yet seldom seen entity—ovarian collision tumor. Natl J Lab Med. 2015;24:25-7.

9. Bostanci MS, Yildirim OK, Yildirim G, Bakacak M, Ekinci ID, Bilgen S, Attar R. Collision tumor: dermoid cysts and mucinous cystadenoma in the same ovary and a review of the literature. Obstet Gynecol Cases Rev. 2015;2(2):1-3.

10. Kalonia T, Kumari N, Malik A, Kumar A, Bahadur A, Kishore S. A rare combination of dermoid cyst and cystadenoma: are collision tumors in the ovary a real entity? Autops Case Rep. 2021 Mar 15;11:e2021249.

11. Bulte CA, Hoegler KM, Khachemoune A. Collision tumors: a review of their types, pathogenesis, and diagnostic challenges. Dermatol Ther. 2020 Nov;33(6):e14236.

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Published

30-04-2025

How to Cite

1.
Bordoloi P, Devi J, Dowerah E. Histopathology of Ovarian Collision Tumor: A Rare Case Report. Ann of Pathol and Lab Med [Internet]. 2025 Apr. 30 [cited 2025 May 18];12(4):C37-41. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/3478

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Section

Case Report