Estimation of Parameters of Haematological Scoring System in Early Diagnosis of Neonatal Sepsis
DOI:
https://doi.org/10.21276/apalm.3514Keywords:
Absolute Neutrophil Count, Platelets, Haematological scoring systemAbstract
Background: Neonatal septicemia is one of the major factors contributing to high perinatal and neonatal mortality and morbidity. The definite diagnosis of septicemia is made by a positive blood culture which requires a minimum period of 48-72 hours and yields a positive result in 30-70% of cases. Hence there is a critical need for laboratory tests that aid in rapid diagnosis of neonatal sepsis.
Materials and Methods: Study was conducted in neonates with suspicion of sepsis admitted to NICU. Prospective study was done for 114 clinically suspected neonatal septicemia cases. Hematological parameters were measured and culture positivity and CRP was taken as the criterion for definitive diagnosis of neonatal septicemia.
Results: 59.6% were culture & CRP positive, 67% were male, and 67% were low birth weight neonates (<2.5 kg). Immature PMN cell, Immature: Total Neutrophil Ratio and Immature: Mature Neutrophil Ratio shows highest sensitivity (69%), Total Leucocyte Count shows highest specificity (70%) and Platelet count shows highest predictive values.
Conclusion: Hematological parameters are particularly useful in resource poor settings for early screening of septicemia as availability of blood culture is limited and time consuming. Clinical profile of neonates was also useful in screening of infected individuals. So, amalgamation of clinical and hematological parameters is useful in screening as it is simple, quick, cost effective and readily available tool.
References
1. Rodwell, R. L., Leslie, A. L., & Tudehope, D. I. (1988). Early diagnosis of neonatal sepsis using a hematologic scoring system. The Journal of pediatrics, 112(5), 761-767.
2. Nayana NS, Sreenivas N. Neonatal Septicemia- A Smooth Technique of Diagnosis in Developing Countries. Int J Res Med Sci 2016 4(6):2305-8.
3. Priyanka T H. Basic Haematological Scoring System-Is It The Most Accurate Neonatal Sepsis Predictor July 2018;7(3):PO29-PO33
4. Panwar C, Kaushik SL, Kaushik R, Sood A. Correlation of Neonatal and Maternal Clinico-Hematological Parameters as Predictors of Early Onset Neonatal Sepsis. Int J Contemp Pediatr Jan 2017;4(1):36-42.
5. Naik SA, Ahmad A, Irshad M, Et Al. Clinical Profile and Bacteriological Spectrum of Neonatal Sepsis, In A Tertiary Care Hospital, Kashmir India. J. Evolution Med. Dent. Sci. 2019:8(06):346-351.
6. Lal S, Shankar M, Adhikari BC, Chaudhary AK. Study of Hematological Parameters in The Early Diagnosis of Neonatal Sepsis in Tertiary Care Center in Jharkhand. Indian J Child Health. 2020; 7(2):82-84
7. Hiral PS, Bharti MJ. Early Diagnosis and Evaluation of Neonatal Septicemia by Haematological Scoring System. Int J Med Sci Public Health 2019;8(6):409-414.
8. Sawadkar, Dr & Dharwadkar, Dr & Gore, Charusheela & Chandanwale, Shirish & Buch, Archana. (2020). Hematological Scoring System and its Significance in Early Diagnosis of Neonatal Sepsis. Saudi Journal of Pathology and Microbiology. 05. 108-114. 10.36348/sjpm.2020.v05i02.012.
9. Dey, Dipika & Sulltana, Razia & Ahmed, Wazir & Chowdhury, Mahmood & Akter, Farhana & Dasgupta, Srabony. (2020). Role of Hematological Score in Early Diagnosis of Neonatal Sepsis. Chattagram Maa-O-Shishu Hospital Medical College Journal. 18. 45-48. 10.3329/cmoshmcj.v18i2.47776.
10. Pramana, K., Kardana, I., Nilawati, G. 2016. Diagnosis accuracy of hematological scoring system in early identification of neonatal sepsis. Bali Medical Journal 5(3): 488-492.
11. Narasimha A, Kumar MLH. Significance of hematological scoring system (HSS) in early diagnosis of neonatal sepsis. Indian J Hematol Blood Transfus. 2011;27:14-7
12. Anwer SK, Mustafa S. Rapid identification of neonatal sepsis. J Pak Med Assoc. 2000 50:94-8.
13. Makkar M. Gupta C, Pathak R, Garg S, Mahajan NC. Performance evaluation of hematologic scoring system in early diagnosis of neonatal sepsis. J Clin Neonatol 2013 2:25-9
14. Basu S, Guruprasad, Narang A, Garewal G. Diagnosis of sepsis in the high-risk neonate using a hematologic scoring system. Indian J Hematol Blood Transf. 1999;17:32-4
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