Clear Cell Carcinoma of Ovary: A Rare Clinico-Pathological Entity

Natasha Dogra; Divya Shelly; Elton Nathaniel Israel; Pallavi Verma; Amit Kumar Das

doi:10.21276/apalm.3534

Clear Cell Carcinoma of Ovary: A Rare Clinico-Pathological Entity

Authors

Natasha Dogra Dept of Pathology, INHS Asvini, Mumbai
Divya Shelly Dept of Pathology, INHS Asvini, Mumbai
Elton Nathaniel Israel Dept of Pathology, INHS Asvini, Mumbai
Pallavi Verma Dept of Pathology, INHS Asvini, Mumbai
Amit Kumar Das Dept of Pathology, INHS Asvini, Mumbai

DOI:

https://doi.org/10.21276/apalm.3534

Keywords:

Ovarian Carcinoma, Clear Cell Carcinoma, Napsin

Abstract

Clear cell carcinoma of ovary is rare neoplasm and has varied clinical manifestations. Mean age at presentation is between 40-70 years. We report a case of a 53 year old female who presented with complaints of of pain, lower abdomen. Imaging revealed a large ovarian mass with multiple metastatic deposits at presentation. Morphology and IHC favored a diagnosis of Clear cell carcinoma of left ovary. This case is presented for its rarity, varied histomorphology, morphological overlap with the commoner serous carcinoma of Ovary and and its poor response to conventional chemotherapy.

References

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2. Prat J, D'Angelo E, Espinosa I. Ovarian carcinomas: at least five different diseases with distinct histological features and molecular genetics. Hum Pathol. 2018:80:11-27.

3. Gadducci A, Multinu F, Cosio S, Carinelli S, Ghioni M, Aletti GD, et al. Clear cell carcinoma of the ovary: Epidemiology, pathological and biological features, treatment options and clinical outcomes. Gynecol Oncol. 2021;162(3):741-50.

4. Kurman RJ, Carcangiu ML, Herrington CS, Young RH, editors. WHO classification of tumors of female reproductive organs. Lyon: IARC; 2014.

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Published

20-11-2025

How to Cite

Dogra N, Shelly D, Israel EN, Verma P, Das AK. Clear Cell Carcinoma of Ovary: A Rare Clinico-Pathological Entity. Ann of Pathol and Lab Med [Internet]. 2025 Nov. 20 [cited 2025 Dec. 5];12(11):C193-C195. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/3534

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Issue

Vol. 12 No. 11 (2025)

Section

Case Report

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