Inflammatory Fibroid Polyp: A Rare Cause of Ileo-ileal Intussusception in Adolescents-Case Report and Review of Literature

Authors

  • Nikita Prasad Department of Pathology, Kalpana Chawla Medical College, Karnal, Haryana, India
  • Hemlata Kamra Department of Pathology, Kalpana Chawla Medical College, Karnal, Haryana, India
  • Upender Sharma Department of Pathology, Kalpana Chawla Medical College, Karnal, Haryana, India

DOI:

https://doi.org/10.21276/apalm.3575

Keywords:

Inflammatory fibroid polyp, Vanek's tumor, Gastrointestinal, Polyp

Abstract

Inflammatory fibroid polyp (IFP) of the gastrointestinal tract (GIT) is a rare benign polypoidal mesenchymal tumor. It most often affects middle-aged adults with a variable clinical presentation. The most common site is the stomach, followed by the small intestine. We report a case of a 16-year-old male who presented with the classical features of intussusception. Surgical resection of the ileocecal region revealed a pedunculated polypoidal mass. Histopathological examination showed a submucosal tumor with an onion-skin appearance comprising spindle cells, loose stroma, and mixed inflammatory infiltrate, predominantly eosinophils. IFP should be considered in the differential diagnosis even in pediatric patients with intestinal obstruction because of its bearing on management.

References

1. Saeed R. Hassan M. Tul-Zahra F, Neary P. Ileo-ileal intussusception due to inflammatory fibroid polyp: a rare cause of small bowel obstruction in adults. J Surg Case Rep. 2022(6):rjac303.

2. Kao YK, Chen JH. Adult Jejuno-jejunal intussusception due to inflammatory fibroid polyp: A case report and literature review. Medicine (Baltimore). 2020;99(36):e22080.

3. Akbulut S. Intussusception due to inflammatory fibroid polyp: a case report and comprehensive literature review. World J Gastroenterol. 2012:18(40):5745-52.

4. Vanek J. Gastric submucosal granuloma with eosinophilic infiltration. Am J Pathol. 1949;25(3):397-411.

5. Adams HS, Bergstrom B, Haines B, Roberts N. Inflammatory Fibroid Polyp: An Unusual Cause of Ileoileal Intussusception. Case Rep Surg. 2017 2017:6315934.

6. Woodward K, Gangarosa LM, Hunt HV. Gastric inflammatory fibroid polyp. Indian J Pathol Microbiol. 2011:54:622-3.

7. Siminas S, Qasem E, Shukla R, Turnock R. Inflammatory fibroid polyp: a rare benign tumor of the alimentary tract in children presenting as intussusception-case report and review of literature. European J Pediatr Surg Rep. 2014;2(1):16-9.

8. Helwig EB, Ranier A. Inflammatory fibroid polyps of the stomach. Surg Gynecol Obstet. 1953;96(3):335-67.

9. Schildhaus HU, Cavlar T, Binot E. Buttner R, Wardelmann E, Merkelbach-Bruse S. Inflammatory fibroid polyps harbour mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene. J Pathol. 2008;216(2):176-82.

10. Nonose R, Valenciano JS, da Silva CM, de Souza CA, Martinez CA. Ileal Intussusception Caused by Vanek's Tumor: A Case Report. Case Rep Gastroenterol. 2011;5:110-6.

11. Gupta R. Pokharia P, Kaur A. Adult Ileo-ileal Intussusception due to Inflammatory Fibroid Polyp. J Gastrointest Surg. 2020:24:1439-40.

12. Unal KD, Cakir E, Dirilenoglu F, Bolat KB, Ekinci N, Akder SA. Analysis of clinical and pathological findings in inflammatory fibroid polyps of the gastrointestinal system: a series of 69 cases. Ann Diagn Pathol. 2018:37:47-50.

13. Wysocki AP, Taylor G, Windsor JA. Inflammatory fibroid polyps of the duodenum: A review of the literature. Dig Surg. 2007;24(3):162-8.

14. Garmpis N, Damaskos C, Garmpi A, Georgakopoulou VE, Sakellariou S, Liakea A, et al. Inflammatory Fibroid Polyp of the Gastrointestinal Tract: A Systematic Review for a Benign Tumor. In Vivo. 2021;35(1):81-93.

15. Karuhanga T. Ngimba C. Yahaya JJ. Inflammatory Fibroid Polyp in a 48-Year-Old Male: A Rare Cause of Intussusception. Case Rep Surg. 2020 2020:9251042.

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Published

30-07-2025

How to Cite

1.
Prasad N, Kamra H, Sharma U. Inflammatory Fibroid Polyp: A Rare Cause of Ileo-ileal Intussusception in Adolescents-Case Report and Review of Literature. Ann of Pathol and Lab Med [Internet]. 2025 Jul. 30 [cited 2025 Dec. 5];12(7):C92-96. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/3575

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Section

Case Report