Understanding the Histomorphological Spectrum of Psoriasiform Dermatitis
DOI:
https://doi.org/10.21276/apalm.3630Keywords:
psoriasiform dermatitis, psoriasis, dermatitis, histomorphological spectrumAbstract
Background: Psoriasiform dermatitis is a term that refers to a group of disorders which histologically and/or clinically mimic psoriasis. It often poses diagnostic dilemma to both pathologists and dermatologists. It is essential to follow a systematic approach and use appropriate clinicopathological correlation to arrive at a diagnosis. Histopathological material constitutes definite hard evidence, which can be preserved and will continue to be available for future review. The objective of this study is to understand the histopathological features of psoriasiform disorders and to highlight the characteristic microscopic difference between them for better approach of the diagnosis.
Methods: This was a retrospective cross-sectional study conducted at tertiary care hospital in Bangalore. All cases diagnosed as psoriasis or mentioned as one of the differential diagnoses were included in the study. The material included 25 skin biopsies.
Results: Most of the cases were noted in the age group of 21-30 years. The sex distribution pattern revealed male predominance with male to female ratio of 1.7:1. Psoriasis was the most common lesion noted followed by Pityriasis rosea and Pityriasis rubra pilaris. Parakeratosis and acanthosis were the most common histological features observed in cases of psoriasis. Dermal infiltrate and acanthosis were the common feature which was seen in almost all biopsy samples.
Conclusion: Clinically, psoriasiform lesions appear as classical psoriasis, however microscopically there are different classifications of psoriasiform disorders. Since satisfactory management of these conditions require both symptomatic and specific therapy, it is essential to reach a definitive diagnosis. Histopathology is the gold standard for diagnosis. Clinicopathological correlation is must for correct diagnosis and appropriate treatment.
References
1. Jayalakshmy, PL., Babitha, AM., Sankar, S., Nandakumar G (2016) Histopathological spectrum of Psoriasiform dermatitis. J of Pathology of Nepal 6:975-980.
2. Kumari Kalpana, MK (2017) A Detailed Study of Histomorphological Spectrum of Psoriasiform Dermatitis. Ind J of Path: Research and Practice;6(2):410-414.
3. Alexander, E., Pinto, J., Pai, GS., Kamath, N., Kuruvilla, M Disease concomitance in psoriasis: a clinical study of 61 cases. Indian J Dermatol Venerol Leprol 67:66-8.
4. Kaur, I., Kumar, B., Sharma, VK (1986) Kaur S. Epidemiology of psoriasis in a clinic from North India. Indian J Dermatol Venerol Leprol 52:208-12
5. Yang, Y., Koh, D., Khoo, L., Nyunt, SZ., Ng, V., Goh,CL(2005) The psoriasis disability index in Chinese patients: Contribution of clinical and psychological variables. Int J Dermatol;44:925-9.
6. Arora, D., Mittal, A., Ahmad, F., Dutta, S., Awasthi S (209) The spectrum of histomorphological features in psoriasis: a three years study. Pathology Update: Tropical Journal of Pathology & Microbiology;5(2):58-62.
7. Thomas, J., Kumar, NA., Manoharan, D., Cynthia, S., Prabu, SKS., Ahmed, NA (2009) A study of comorbid conditions in psoriasis. Journal of Pakistan Association of Dermatologists; 19:200-2.
8. Puri, N., Mahajan, BB., Kaur, S (2012) Clinico-histopathological Correlation of Psoriasis in Acute Exacerbation. 1:455.
9. Park, JH., Park, YJ., Kim, SK (2016) Histopathological Differential Diagnosis of Psoriasis and Seborrheic Dermatitis of the Scalp. Ann Dermatol. 28(4):427-32.
10. Mehta, S., Singal, A., Singh, N., Bhattacharya SN (2009) A study of clinicohistopathological correlation in patients of psoriasis and psoriasiform dermatitis. Indian J Dermatol Venereol Leprol 75:100.
11. Chanadanwale, SS., Panicker, NK., Kulkarni, SP., Shah, KR., Kumar, H., Sharma YK, et al (2015) Morphometry analysis of psoriasis and psorasiform dermatitis: A retrospective study of 50 Cases. Med J DY Patil Univ;8:43-7.
12. GhasemiBasir, HR., Alirezaei, P., Hamian, Z. et al (2018) Are quantitative histopathologic criteria capable of differentiating psoriasis from chronic dermatitis? Clin Cosmet Investig Dermatol. 10:11:239-244.
13. Lever, WF, Elder, DE (2015) Lever's histopathology of the skin / editor, David E, Elder D. 11th edition. Philadelphia: Wolters Kluwer Health/Lippincott Williams and Wilkins: 181.
14. Elder DE, Elenitsas R, Jaworsky C, Johnson B Jr, editors. Lever's Histopathology of the skin. 8th ed. Philadelphia (PA): Lippincott- Raven; 1997. p.156-63.
15. Altman, EM., Kamino H (1999) Diagnosis: psoriasis or not? What are the clues? Semin Cutan Med Surg. 18(1):25-35.
16. Prasad, D., Mittal, RR., Walia, R., Popli, R (2014) Pityriasis rosea: A histopathologic study. Indian J Dermatol Venereol Leprol 2000;66:244-6.
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Copyright (c) 2025 Divya Rani M N, Sreedevi P, Roopa A N, Sowmya S M, Diya Bashetty, Shyam V
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