Large Odontogenic Fibroma of the Mandible Mimicking Malignancy in an Adolescent Male: Diagnosis Unveiled on Histopathology
DOI:
https://doi.org/10.21276/apalm.3651Keywords:
Odontogenic, fibroma, mandible, tumour, oral cavityAbstract
Background: Odontogenic fibroma is a very rare benign tumour of the jaw with an overall incidence of less than 1% of all odontogenic tumours. It can either be unilocular or multilocular cystic tumour with a significant overlap between clinical and radiological findings amongst different odontogenic tumours of oral cavity.
Case report: We present a case of an odontogenic fibroma of mandible in a 14-year old boy, which was clinically suspected to be osteosarcoma with radiological differentials of odontogenic myxoma and ossifying fibroma. Histopathological examination showed a tumour composed of variably cellular fibroblastic stroma with bits of lamellar bone showing osteoblastic rimming. Interspersed strands of bland odontogenic epithelium and multinucleated giant cells were noted. There was no mitosis or atypia. Final diagnosis of odontogenic fibroma was rendered on histopathologic examination of the biopsy specimen.
Conclusion: This case report highlights the role of histopathological examination in diagnosing odontogenic fibroma, which can easily be missed due to clinical and radiological similarities with other benign and malignant entities.
References
1. Schultz LW and Vazirani SL. Central odontogenic fibromyxoma of the mandible. Oral Surg Oral Med Oral Path 1957; 10: 690-5.
2. Wright JM, Soluk-Tekkesin M, Eds. Odontogenic and maxillofacial bone tumours. In: WHO Classification of Head and Neck tumours. 5th ed. Lyon: IARC Press; 2022. p.563-751.
3. Poomsawat S, Choakdeewanitthumrong S, Kitisubkanchana J, Kosanwat T. Central odontogenic fibroma: retrospective study of six cases with variable histopathologic features using 2022 WHO classification. BMC Oral Health. 2024 Oct 26;24(1):1297.
4. Tekkesin MS. Wright JM. The World Health Organization Classification of Odontogenic Lesions: A Summary of the Changes of the 2022 (5th) Edition. Turk Patoloji Derg 2022; 38: 168-84.
5. Pindborg JJ, Kramer IRH, Torloni H, Eds. Histological typing of odontogenic tumours, jaw cysts, and allied lesions. In: International Histological classification of tumours. 2nd ed vol5. Geneva: World Health Organization; 1971. p.1-36.
6. Wesley RK, Wysocki GP, Mintz SM. The central odontogenic fibroma. Clinical and morphological studies Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1975:40:235-45
7. Bennabi S, Lesclous P, Cloitre A. Central odontogenic fibroma: characteristics and management. J Oral Med Oral Surg. 2021;27(2):1-9.
8. Gardner DG. The central odontogenic fibroma; An attempt at clarification Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1980:5:425-32
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