Association of Serum Magnesium and Insulin Resistance in Type 2 Diabetes Mellitus: A Meta-Analysis
DOI:
https://doi.org/10.21276/apalm.3663Keywords:
serum magnesium, insulin resistance, HOMA-IR, type 2 diabetes mellitusAbstract
Background: This study aims to systematically review observational studies and, where possible, conduct a meta-analysis on the association between serum magnesium levels and Insulin Resistance (IR) in patients with T2DM.
Method: All observational studies published in peer-reviewed journals in Google Scholar, PubMed Central and PubMed were searched to identify related articles published in previous 10 years up to 3rd March 2025 were included in our study. An analysis of studies that explored the relationship between magnesium intake, serum magnesium levels, and metabolic syndrome in patients with diabetes mellitus. Patients diagnosed with polycystic ovary syndrome or cardiac syndrome or morbidly obese individuals were excluded from our study.
Result: A total of 22605 articles identified, and after excluding 22,580 articles based on their titles and abstracts, 16 of the remaining 25 full-text articles were also excluded. Finally, 9 articles were approved for the study and 8 articles for meta-analysis. RE (Random Effect) Model shows a negative correlation of -0.49, with a confidence interval of -0.76 to -0.23, suggesting a statistically significant negative association between serum magnesium and HOMA-IR in T2DM across the included studies.
Conclusion: Insulin resistance (HOMA-IR) was reported to be substantially linked with hypomagnesemia in T2DM, this could also raise the risk of uncontrolled diabetes and its complications.
References
1. Khan M.A.B., Hashim M.J., King J.K., Govender R.D., Mustafa H., Al Kaabi J. Epidemiology of Type 2 Diabetes—Global Burden of Disease and Forecasted Trends. J. Epidemiol. Glob. Health. 2020;10:107–111. doi: 10.2991/jegh.k.191028.001.
2. Li W, Jiao Y, Wang L, Wang S, Hao L, Wang Z, Wang H, Zhang B, Ding G, Jiang H. Association of Serum Magnesium with Insulin Resistance and Type 2 Diabetes among Adults in China. Nutrients. 2022 Apr 25;14(9):1799. doi: 10.3390/nu14091799. PMID: 35565766; PMCID: PMC9104014.
3. Chutia H, Lynrah KG. Association of Serum Magnesium Deficiency with Insulin Resistance in Type 2 Diabetes Mellitus. J Lab Physicians. 2015 Jul-Dec;7(2):75-8. doi: 10.4103/0974-2727.163131. PMID: 26417155; PMCID: PMC4559632.
4. American Diabetes Association. Diabetes Care. 2014;37 Suppl 1:S81–90. doi: 10.2337/dc14-S081.
5. Hanefeld M. The metabolic syndrome: Roots, myths, and facts. In: Hanefeld M, Leonhardt W, editors. The Metabolic Syndrome. Jena: Gustav Fischer; 1997. pp. 13–24.
6. Kuppusamy S, Dhanasinghu R, Sakthivadivel V, Kaliappan A, Gaur A, Balan Y, Tadi LJ, Sundaramurthy R. Association of Serum Magnesium with Insulin Indices in Patients with Type 2 Diabetes Mellitus. Maedica (Bucur). 2022 Sep;17(3):596-601. doi: 10.26574/maedica.2022.17.3.596. PMID: 36540586; PMCID: PMC9720662.
7. Vazquez Rocha L, Macdonald I, Alssema M, Færch K. The Use and Effectiveness of Selected Alternative Markers for Insulin Sensitivity and Secretion Compared with Gold Standard Markers in Dietary Intervention Studies in Individuals without Diabetes: Results of a Systematic Review. Nutrients 2022, 14, 2036. https://doi.org/10.3390/nu14102036.
8. Erinc O, Yesilyurt S. Relationship between serum magnesium levels and glycemic control and insulin resistance. Northern Clinics of İstanbul. Diab Met Syndr: Clin Res Rev. 2015. 25;12(2):239–243. doi: 10.14744/nci.2024.75725.
9. Kostov K. Effects of Magnesium Deficiency on Mechanisms of Insulin Resistance in Type 2 Diabetes: Focusing on the Processes of Insulin Secretion and Signaling. Int J Mol Sci. 2019 Mar 18;20(6):1351. doi: 10.3390/ijms20061351. PMID: 30889804; PMCID: PMC6470576.
10. Rosanoff A, West C, Elin RJ, Micke O, Baniasadi S, Barbagallo M, Campbell E, Cheng FC, Costello RB, et al. Recommendation on an updated standardization of serum magnesium reference ranges. Eur J Nutr. 2022 Oct;61(7):3697-3706. doi: 10.1007/s00394-022-02916-w.
11. Horáková D, Štěpánek L, Janout V, Janoutová J, Pastucha D, Kollárová H, Petráková A, Štěpánek L, Husár R, Martiník K. Optimal Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) Cut-Offs: A Cross-Sectional Study in the Czech Population. Medicina (Kaunas). 2019 May 17;55(5):158. doi: 10.3390/medicina55050158. PMID: 31108989; PMCID: PMC6571793.
12. Vidya Sagar Ram, Ashutosh Vishnoi, Mimoh Sharma, Abel Jaison, Nivedita Singh. Unveiling the Role of Magnesium: Insights into Insulin Resistance and Glycemic Control in Type 2 Diabetes. eJIFCC. 2024;35(3):189-194.
13. Beibei Luo, Baolong Pan, Guancheng Zhao, Jiefen Li, Li Sun. Association Between Serum Magnesium Levels and Glycemic Control in Type 2 Diabetes. Diabetes, Metabolic Syndrome and Obesity 2024:17 2823–2829.
14. Akyüz O, Gücün M, Demirci R, et al. Relationship Between Serum Magnesium Level and Insulin Resistance in Turkey Non-obese Adult Population. Biol Trace Elem Res 200, 3070–3077 (2022). https://doi.org/10.1007/s12011-021-02922-9.
15. Adeleye J, Esan A, Azeez TA, Sonuga OO. Correlation of Plasma Magnesium with Insulin Resistance in Type 2 Diabetes: A Cross-Sectional Study from South-Western Nigeria. Journal of Diabetology 12(4):442-446, Oct–Dec 2021. DOI: 10.4103/jod.jod_26_21.
16. Shamnani G, Bhartiy SS, Jiwane R, Gupta V, Verma N, Verma D. Correlation of Serum Magnesium with Insulin Resistance in North Indian Adult Population. Curr Diabetes Rev. 2020;16(3):254-261. doi: 10.2174/1573399814666181016164432. PMID: 30332968.
17. Nehal Hamdy El-said, Noha Adly Sadik, Nagwa Abd EL-Ghaffar Mohammed. Magnesium in type 2 diabetes mellitus and its correlation with glycemic control. Int J Res Med Sci. 2015;3(8):1958-1963.
18. Sperling MA, Tamborlane WV, Battelino T, Weinzimer SA, Phillip M. Chapter 19 – diabetes mellitus, in: Sperling MA (Ed.), Pediatric Endocrinology, 4th Ed. W.B. Saunders, 2014, pp. 846–900. doi:10.1016/B978-1-4557-4858-7.00028-7.
19. DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, Hu FB, Kahn CR, Raz I, Shulman GI, Simonson DC, Testa MA, Weiss R. Type 2 diabetes mellitus. Nat Rev Dis Primers 1 (2015) 1–22. doi:10.1038/nrdp.2015.19.
20. Ashcroft FM, Rorsman P. KATP channels and islet hormone secretion: new insights and controversies. Nat Rev Endocrinol. 9 (2013) 660–669. doi:10.1038/nrendo.2013.166.
21. Fu Z, Gilbert ER, Liu D. Regulation of insulin synthesis and secretion and pancreatic beta-cell dysfunction in diabetes. Curr Diabetes Rev. 9 (2013) 25–53.
22. Al Alawi AM, Majoni SW, Falhammar H. Magnesium and human health: perspectives and research directions. Int J Endocrinol. 2018 (2018) 9041694. doi:10.1155/2018/9041694.
23. Gröber U, Schmidt J, Kisters K. Magnesium in prevention and therapy. Nutrients 7 (2015) 8199–8226. doi:10.3390/nu7095388.
24. de Baaij JHF, Hoenderop JGJ, Bindels RJM. Magnesium in man: implications for health and disease. Physiol Rev. 95 (2015) 1–46. doi:10.1152/physrev.00012.2014.
25. Atalay H. Serum trace elements in type 2 diabetes mellitus. Acta Medica Mediterr. 2017: 795–800. doi:10.19193/0393-6384_2017_5_117.
26. Wei J, Zeng C, Li X, Gong Q, Lei G, Yang T. Association among dietary magnesium, serum magnesium, and diabetes: a cross-sectional study in middle-aged and older adults. J Health Popul Nutr. 35 (2016) 33. doi:10.1186/s41043-016-0071-z.
27. Wahid A, Verma GC, Meena CP, Pathan AR. Study of serum magnesium level in patients with type 2 diabetes mellitus and its correlation with glycosylated hemoglobin and diabetic complications. Int J Adv Med. 4 (2017) 311. doi:10.18203/2349-3933.ijam20170614.
28. Barragán R, Llopis J, Portolés O, Sorlí JV, Coltell O, Rivas-García L, Asensio EM, Ortega-Azorín C, Corella D, Sánchez-González C. Influence of demographic and lifestyle variables on plasma magnesium concentrations and their associations with cardiovascular risk factors in a mediterranean population. Nutrients 12 (2020) 1018. doi:10.3390/nu12041018.
29. Fang X, Han H, Li M, Liang C, Fan Z, Aaseth J, He J, Montgomery S, Cao Y. Dose-response relationship between dietary magnesium intake and risk of type 2 diabetes mellitus: a systematic review and meta-regression analysis of prospective cohort studies. Nutrients 8 (2016) 739. doi:10.3390/nu8110739.
30. Liu H, Li N, Jin M, Miao X, Zhang X, Zhong W. Magnesium supplementation enhances insulin sensitivity and decreases insulin resistance in diabetic rats. Iran J Basic Med Sci. 2020 Aug;23(8):990-998. doi: 10.22038/ijbms.2020.40859.9650. PMID: 32952944; PMCID: PMC7478262.
31. Erinc O, Yesilyurt S. Relationship between serum magnesium levels and glycemic control and insulin resistance. Northern Clinics of İstanbul. Diab Met Syndr: Clin Res Rev. 2015. 25;12(2):239–243. doi: 10.14744/nci.2024.75725.
32. Solati M, Ouspid E, Hosseini S, Soltani N, Keshavarz M, Dehghani M. Oral magnesium supplementation in type II diabetic patients. MJIRI. 2014;28:1-8.
33. Dalal D, Joshi A, Jaiswal M. Role of magnesium supplementation on glycaemic control in patients with type 2 diabetes mellitus: a prospective, double-blind, placebo-controlled study. International Journal of Advances in Medicine, 12(4), 371–375. https://doi.org/10.18203/2349-3933.ijam20251934.
34. Xu L, Li X, Wang X, Xu M. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes. A pooled analysis of 24 randomized controlled trials. Front Nutr. 9:1020327. doi: 10.3389/fnut.2022.1020327.
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