Correlation Between Serum Ferritin Levels and Glycemic Control in Type 2 Diabetes Mellitus: A Case-Control Study

Pushpanjali Behera; Sugatha Sahu; Anu Singh; Anju Bharti

doi:10.21276/apalm.3776

Authors

Pushpanjali Behera Department of Pathology, IMS and SUM Hospital, Bhubaneswar, India
Sugatha Sahu Department of Pathology, IMS and SUM Hospital, Bhubaneswar, India
Anu Singh Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
Anju Bharti Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

DOI:

https://doi.org/10.21276/apalm.3776

Keywords:

HbA1c, ferritin, diabetes mellitus, glycemic control

Abstract

Background: Diabetes mellitus is a global health crisis affecting major population. There are various prognostic factors related to the disease. This study was done to assess the correlation between serum ferritin levels and fasting blood sugar (FBS) and glycated hemoglobin (HbA1c) in T2DM patients compared to normal control.

Methods: A case-control study involving 100 participants (50 T2DM patients and 50 healthy controls) was conducted. Serum ferritin, fasting blood sugar (FBS), and glycated hemoglobin (HbA1c) levels were measured. Statistical analysis included t-tests for group comparisons and Pearson's correlation to assess associations between variables. Data were analyzed using SPSS v17. Continuous variables were expressed as mean ± standard deviation (SD). Statistical significance was set.

Results: Serum ferritin levels were significantly higher in T2DM patients (113.13 ± 44.29 ng/mL) compared to controls (24.38 ± 11.04 ng/mL, p<0.001). A strong positive correlation was observed between serum ferritin and HbA1c (r=0.971, p<0.001).

Conclusion: Elevated serum ferritin levels are strongly associated with poor glycemic control in T2DM. These findings suggest ferritin's potential as a biomarker for diabetes management and progression.

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