Matrix-Producing Metaplastic Carcinoma of the Breast with Predominant Chondroid Differentiation: An Unusual Presentation with Diagnostic Dilemma
DOI:
https://doi.org/10.21276/apalm.3844Keywords:
metaplastic breast carcinoma, matrix-producing, chondroid differentiation, breast sarcoma, nodal metastasisAbstract
We report a rare case of matrix-producing metaplastic carcinoma (MPMC) of the breast in a 50-year-old postmenopausal woman presenting with a rapidly enlarging recurrent breast mass and axillary lymphadenopathy. The tumor showed dominant chondroid differentiation without definitive carcinomatous or spindle cell elements, resulting in major diagnostic challenges. Nodal metastasis, rapid recurrence, and aggressive clinical progression ultimately confirmed the diagnosis of matrix-producing metaplastic carcinoma. This case highlights the diagnostic challenges and emphasizes the importance of correlating clinicopathological features when conventional histomorphology and epithelial markers are lacking.References
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Copyright (c) 2026 Munmun Harlalka, Abhijit Kalita, Nishant Lohia
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