Rare Coexistence of Bilateral Mucinous Cystadenoma and Benign Brenner Tumor

Authors

  • Bhavna Sharma Department of Pathology, ESIC Medical College and PGIMSR, Basaidarapur, New Delhi, India
  • Udita Anand Department of Pathology, ESIC Medical College and PGIMSR, Basaidarapur, New Delhi, India
  • Sujata Raychaudhuri Department of Pathology, ESIC Medical College and PGIMSR, Basaidarapur, New Delhi, India
  • Priyanka Munjal Department of Pathology, ESIC Medical College and PGIMSR, Basaidarapur, New Delhi, India

DOI:

https://doi.org/10.21276/apalm.3846

Keywords:

mucinous, cystadenoma, brenner, bilateral, coexistence

Abstract

Introduction: Coexistence of ovarian mucinous cystadenoma with benign Brenner tumor is a rare entity. Bilateral coexistence has not been reported before. Case Presentation: A 58-year-old postmenopausal woman presented with progressive abdominal distension and pain. Imaging revealed a large multilocular cystic mass without obvious solid components in the left ovary whereas right ovary was not clearly visualized due to adhesions. Gross and microscopic examination revealed presence of mucinous cystadenoma and benign Brenner tumor in both the ovaries.

Discussion: This case highlights the importance of thorough gross and microscopic evaluation of ovarian tumors to identify coexisting neoplasms. Knowledge about such coexistence is a must for pathologists as well as surgeons as it may influence treatment decisions.

References

1. Maghbool M, Samizadeh B. Mixed mucinous cystadenoma with benign Brenner tumor in a huge ovarian mass: a case report and review of literature. Int J Surg Case Rep. 2022;92:106859.

2. D. Dougherty, C. Onyemkpa, M. Engel, T. Oyasiji. A case report of an incidental brenner tumor found after resection of a large ovarian mucinous neoplasm. Int. J. Surg. Case Rep. 2018;49:40–43.

3. Frezgi O, Tesfamichael T, Farah KH, Gebremariam H, Wahaballa YD, Tesfai B. Benign Brenner Tumor Mixed with Mucinous Cystadenoma of the Left Ovary: Case Report and Literature Review. Int J Womens Health. 2024;16:1671-1675.

4. Wilson MP, Katlariwala P, Hwang J, Low G. Radiographic features of a benign mixed Brenner tumor and mucinous cystadenoma: a rarely identified ovarian neoplasm on imaging. J Clin Imaging Sci. 2020;10:22.

5. Wang Y, Wu R-c, Shwartz LE, Haley L, Lin M-t, Shih I-m et al. Clonality analysis of combined Brenner and mucinous tumours of the ovary reveals their monoclonal origin. J Pathol. 2015;237:146-151.

6. Tafe LJ, Muller KE, Ananada G, Mitchell T, Spotlow V, Patterson SE. Molecular genetic analysis of ovarian Brenner tumors and associated mucinous epithelial neoplasms: high variant concordance and identification of mutually exclusive RAS driver mutations and MYC amplification. Am J Pathol. 2016;186:671–7.

7. S. Sridevi, Rao V. Manmadha, Kumar S. Satish, A. Bhagyalakshmi. Mucinous cystadenoma with brenner tumor: a case report. J Evid-based Med Healthc. 2015;2:455–458.

8. A.M. Abbas, M.T. Amin. Brenner's tumor associated with ovarian mucinous cystadenoma reaching a huge size in postmenopausal woman. J Cancer Res Ther. 2015;11:1030.

9. P. Pradhan, L. Mohanty, D. Pradhan, S. Pujari, A. Kar. Benign brenner tumor of ovary with mucinous cystadenoma: a case report. Asia J Pharm Health Sci. 2017;7:1643–1646.

10. Anoedward G. Henry AKO, Adeshina S. James, Adegoke O. Omolade, Awotunde T. Olufemi, Lasisi M. Eniola, Jooda K. Olurotimi. Mucinous cystadenoma coexisting with Brenner tumour: a case report. Sudan Med J. 2017;11:1–3.

11. F. Nazari, Z. Dehghani. Coexistence of benign brenner tumor with mucinous cystadenoma in an ovarian mass. Iran J Pathol. 2020;15:334–337.

12. Babaria SS, Mody MB, Suri S, Joshi DS. An incidental finding of benign Brenner tumor in mucinous cystadenoma of ovary: a case report. J Krishna Inst Med Sci Univ. 2022;11:108-111.

13. Joy MA, Ashima, Isaacs R. Coexistence of Benign Brenner Tumor with Mucinous Cystadenoma: A Case Report. Int J Life Sci Biotechnol Pharma Res. 2023;12:2112-2114.

14. Samaddar S, Bhanji AG, Nair VS. Concurrent Benign Brenner Tumor and Mucinous Cystadenoma of an Ovary in a Postmenopausal Woman: A Case Report. Ann of Pathol and Lab Med. 2024;11:76-82.

15. Zahlout J, Shmayyes NA, Zahlout B, Kassab Y, Alshehabi Z. Coexistence of a huge Brenner's tumour and mucinous cystadenoma in a 62-year-old female: a case report from Syria. Ann Med Surg. 2023;85:1852-1856.

Downloads

Published

01-05-2026

Issue

Section

Case Report / Case Series

How to Cite

1.
Rare Coexistence of Bilateral Mucinous Cystadenoma and Benign Brenner Tumor. Ann of Pathol and Lab Med [Internet]. 2026 May 1 [cited 2026 May 5];13(5):C150-C154. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/3846