Interdigitating Dendritic cell sarcoma arising in the cervical node
Keywords:
Immunohistochemistry, Peripheral node, S100Abstract
Inter-digitating dendritic cell (IDC) sarcoma is a rare tumor presenting as an asymptomatic slow growing lesion. The median age of occurrence is around 52 years and has a male preponderance. Peripheral lymphadenopathy is the commonest presenting symptom. The clinical course of patients with IDC sarcoma varies from indolent to more aggressive with widespread metastases and death within a year. There is no standardized therapeutic approach for patients with IDC sarcoma. We are presenting a case of IDC sarcoma in a 40 year old male with cervical node and liver involvement. Histologically, there was complete effacement of nodal architecture with tumor cells arranged in sheets composed of spindle cells and epithelioid cells having convoluted nuclei. Immuno- reactivity for S100 and vimentin were observed. Other stains such as CD3 and CD45 were negative. Histology, Immuno histochemistry and differential diagnosis are discussed in our presentation which would help in arriving at the diagnosis of this rare tumor.References
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2. Venkata K. Pokuri, Mihai Merzianu,Shipra Gandhi, Junaid Baqai, Thom R. Loree, and Seema Bhat, Interdigitating Dendritic Cell Sarcoma, Journal of the National Comprehensive Cancer Network. 2015;13 (2) : 128-132.
3. Gaertner E, Tsokos M, Derringer G, Neuhauser T, Arciero C, Andriko J. Interdigitating Dendritic Cell Sarcoma. American Journal of Clinical Pathology. 2001;115(4):589-597.
4. Fonseca R, Yamakawa M, Nakamura S, van Heerde P, Miettinen M, Shek T et al. Follicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: A review. Am J Hematol. 1998;59(2):161-167.
5. Kanaan H, Al-Maghrabi J, Linjawi A, Al-Abbassi A, Dandan A, Haider R A. Interdigitating Dendritic Cell Sarcoma of the Duodenum With Rapidly Fatal Course: A Case Report and Review of the Literature. Archives of Pathology & Laboratory Medicine.2006; 130(2):205-208.
6. Ohtake H, Yamakawa M. Interdigitating Dendritic Cell Sarcoma and Follicular Dendritic Cell Sarcoma: Histopathological Findings for Differential Diagnosis. Journal of Clinical and Experimental Hematopathology. 2013;53(3):179-184.
7. Lee E, Hyun D, Cho H, Lee J. A Rare Case of Interdigitating Dendritic Cell Sarcoma in the Nasal Cavity. Case Reports in Otolaryngology. 2013;2013:1-4.
8. Barwell N, Howatson R, Jackson R, Johnson A, Jarrett RF, Cook G. Interdigitating dendritic cell sarcoma of salivary gland associated lymphoid tissue not associated with HHV-8 or EBV infection. J Clin Pathol 2004;57: 87-89.
9. Han HS, Lee OJ, Lim SN, An JY, Lee KM, Choe KH, Lee KH , Kim ST: Extranodal interdigitating dendritic cell sarcoma presenting in the pleura: a case report. J Korean Med Sci. 2011; 26: 304-307.
10. De Pas T, Spitaleri G, Pruneri G, Curigliano G, Noberasco C, Luini A, Andreoni B, Testori A, de Braud F. Dendritic cell sarcoma: An analytic overview of the literature and presentation of original five cases. Critical Reviews in Oncology / Hematology.2008; 65(1): 1 – 7.
11. Zhang J, Liu B, Song N, Hua L, Wang Z, Yin C. Interdigitating dendritic cell sarcoma presenting in the kidney combined with retroperitoneal leiomyosarcoma: A case report and literature review. Oncology Letters. 2013; 7: 466-470.
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08-05-2016
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Ibrahim S, Thilagavathy S, Kumari M. Interdigitating Dendritic cell sarcoma arising in the cervical node. Ann of Pathol and Lab Med [Internet]. 2016 May 8 [cited 2024 Nov. 19];3(2):C98-102. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/APALM517
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Copyright (c) 2016 Shifa Ibrahim, Sharmila Thilagavathy, Meena Kumari
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