Seroprevalence of Hepatitis E IgG antibodies among Voluntary Blood Donors in a tertiary hospital
Keywords:
Hepatitis E, parenteral transmission, blood transfusion, maternal mortality, HEV IgGAbstract
Background:Â Transfusion safety is a major concern in medical practice. Hepatitis E is a potential threat among transfusion-transmitted infections. In resource poor settings and in endemic countries, parenteral transmission can occur at an increased rate and leads to subclinical infection. Currently Hepatitis E virus screening is not mandatory in many countries. This can possibly endanger the population.
Methods: We aimed at estimating the seroprevalence of HEV antibodies (IgG) among healthy blood donors in Chennai, South India. A prospective study was conducted among 142 blood donors from January 2016 to November 2016 in a tertiary care teaching hospital. Serum anti HEV IgG antibody was detected by Enzyme Linked Immuno Sorbent Assay (ELISA).
Results:Â Out of 142 samples, 19/142 (13.38%) showed positivity for IgG antibodies for HEV.
Conclusion:Â This study showed the importance of screening for HEV, as there is increased rate of positivity among the blood donors in our study population.
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DOI:Â 10.21276/APALM.1370
References
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15. Dalton HR, Stableforth W, Thurairajah P, Hazeldine S, Remnarace R, Usama W, et al. Autochthonous hepatitis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease. Eur J Gastroenterol Hepatol. 2008 Aug;20(8):784–90.
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18. Anand AC, Singh KJ, Sharma P, Kumar S, Gupta RM. Incidence of Hepatitis E Virus Infection in Recipients of Blood or Blood Products Transfusion. Med J Armed Forces India. 2010 Jul;66(3):204–7.
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2. Irshad M, Sharma Y, Dhar I, Singh J, Joshi Y-K. Transfusion-transmitted virus in association with hepatitis A-E viral infections in various forms of liver diseases in India. World J Gastroenterol. 2006 Apr 21;12(15):2432–6.
3. Pallavi P, Ganesh CK, Jayashree K, Manjunath GV. Seroprevalence and trends in transfusion transmitted infections among blood donors in a university hospital blood bank: a 5 year study. Indian J Hematol Blood Transfus Off J Indian Soc Hematol Blood Transfus. 2011 Mar;27(1):1–6.
4. Juhl D, Baylis SA, Blümel J, Görg S, Hennig H. Seroprevalence and incidence of hepatitis E virus infection in German blood donors. Transfusion (Paris). 2014 Jan;54(1):49–56.
5. Arankalle VA, Chobe LP. Retrospective analysis of blood transfusion recipients: evidence for post-transfusion hepatitis E. Vox Sang. 2000;79(2):72–4.
6. Khuroo MS, Kamili S, Yattoo GN. Hepatitis E virus infection may be transmitted through blood transfusions in an endemic area. J Gastroenterol Hepatol. 2004 Jul;19(7):778–84.
7. Hewitt PE, Ijaz S, Brailsford SR, Brett R, Dicks S, Haywood B, et al. Hepatitis E virus in blood components: a prevalence and transmission study in southeast England. Lancet Lond Engl. 2014 Nov 15;384(9956):1766–73.
8. Anti Hepatitis E Virus Seropositivity in a Group of Blood Donors (PDF Download Available) [Internet]. [cited 2017 Jan 24]. Available from: https://www.researchgate.net/publication/237261115_Anti_Hepatitis_E_Virus_Seropositivity_in_a_Group_of_Blood_Donors
9. Bortoliero AL, Bonametti AM, Morimoto HK, Matsuo T, Reiche EMV. Seroprevalence for hepatitis E virus (HEV) infection among volunteer blood donors of the Regional Blood Bank of Londrina, State of Paraná , Brazil. Rev Inst Med Trop Sao Paulo. 2006 Apr;48(2):87–92.
10. Takahashi M, Tamura K, Hoshino Y, Nagashima S, Yazaki Y, Mizuo H, et al. A nationwide survey of hepatitis E virus infection in the general population of Japan. J Med Virol. 2010 Feb;82(2):271–81.
11. Daniel HDJ, Warier A, Abraham P, Sridharan G. Age-wise exposure rates to hepatitis e virus in a southern Indian patient population without liver disease. Am J Trop Med Hyg. 2004 Nov;71(5):675–8.
12. Gajjar MD, Bhatnagar NM, Sonani RV, Gupta S, Patel T. Hepatitis E seroprevalence among blood donors: A pilot study from Western India. Asian J Transfus Sci. 2014 Jan;8(1):29–31.
13. Mateos ML, Camarero C, Lasa E, Teruel JL, Mir N, Baquero F. Hepatitis E virus: relevance in blood donors and other risk groups. Vox Sang. 1998;75(4):267–9.
14. Meng XJ, Wiseman B, Elvinger F, Guenette DK, Toth TE, Engle RE, et al. Prevalence of antibodies to hepatitis E virus in veterinarians working with swine and in normal blood donors in the United States and other countries. J Clin Microbiol. 2002 Jan;40(1):117–22.
15. Dalton HR, Stableforth W, Thurairajah P, Hazeldine S, Remnarace R, Usama W, et al. Autochthonous hepatitis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease. Eur J Gastroenterol Hepatol. 2008 Aug;20(8):784–90.
16. Ijaz S, Arnold E, Banks M, Bendall RP, Cramp ME, Cunningham R, et al. Non-travel-associated hepatitis E in England and Wales: demographic, clinical, and molecular epidemiological characteristics. J Infect Dis. 2005 Oct 1;192(7):1166–72.
17. Mansuy JM, Legrand-Abravanel F, Calot JP, Peron JM, Alric L, Agudo S, et al. High prevalence of anti-hepatitis E virus antibodies in blood donors from South West France. J Med Virol. 2008 Feb;80(2):289–93.
18. Anand AC, Singh KJ, Sharma P, Kumar S, Gupta RM. Incidence of Hepatitis E Virus Infection in Recipients of Blood or Blood Products Transfusion. Med J Armed Forces India. 2010 Jul;66(3):204–7.
19. Gotanda Y, Iwata A, Ohnuma H, Yoshikawa A, Mizoguchi H, Endo K, et al. Ongoing subclinical infection of hepatitis E virus among blood donors with an elevated alanine aminotransferase level in Japan. J Med Virol. 2007 Jun 1;79(6):734–42.
20. art22532.pdf [Internet]. [cited 2017 Jan 21]. Available from: http://www.eurosurveillance.org/images/dynamic/EE/V21N30/art22532.pdf
21. Original Article (Ravinder) - Vol1Issue3_41OA.pdf [Internet]. [cited 2017 Jan 21]. Available from: http://aimdrjournal.com/pdf/Vol1Issue3_41OA.pdf
22. Retrospective serological analysis of hepatitis E patients: a long-term follow-up study. [Internet]. [cited 2017 Jan 24]. Available from: http://www.medscape.com/medline/abstract/10607264
23. Bajpai M, Gupta E. Transfusion-transmitted hepatitis E: Is screening warranted? Indian J Med Microbiol. 2011 Oct 1;29(4):353.
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30-10-2017
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Luck CP, Jamuna Rani S, Jeyakumari D, Balamurugan M, Padmavathi AV, Nasrin K. Seroprevalence of Hepatitis E IgG antibodies among Voluntary Blood Donors in a tertiary hospital. Ann of Pathol and Lab Med [Internet]. 2017 Oct. 30 [cited 2024 Nov. 19];4(5):A599-603. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm1370
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Copyright (c) 2017 Chinnadurai Peermohd Luck, Srirangramasamy Jamuna Rani, Duraipandian Jeyakumari, Madasamy Balamurugan, Aruna V Padmavathi, Kolsamma Nasrin
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