Study on Mean Platelet Volume And Platelet Count In Diabetes Mellitus Type 2
Keywords:
Diabetes mellitus, Fasting blood sugar, Mean Platelet Volume, Platelet countAbstract
Background: Most Diabetes Mellitus related deaths are due to increased risk of micro- and macrovascular complications of the disease. Larger platelets with higher mean platelet volume increase the propensity to thrombosis. Therefore, increased MPV is emerging as a risk factor for vascular complications.
Methods: This prospective study was conducted on 100 subjects with type II DM and 50 non-diabetic controls over a period of 3 months. To determine mean platelet volume (MPV) and platelet count (PC) in diabetics (type2) and non-diabetics and to determine correlation of MPV and platelet count with fasting blood sugar.
Results: Significant  increase in value of MPV was seen in diabetics.
Conclusion: MPV being a simple, economical test, can serve as an effective tool in monitoring the patients for thrombogenicity especially in patients with altered blood glucose metabolism.
Â
Â
DOI:Â 10.21276/APALM.1381
Â
References
2. Yenigün E. Increased mean platelet volume in type 2 diabetes mellitus. Dicle Medical Journal/Dicle Tıp Dergisi. 2014;41(1):17-22.
3.Mahsud MAJ, Khan A, Hussain J. Hematological Changes in Tobacco using Type 2 Diabetic Patients.Gomal J Med Sci 2010;8:8-11.
4.King H, Aubert Re, Herman WH. Global burden of diabetes,1995-2025: prevelance, numerical estimates, and projections. Diabetes Care 1998;21:1414-31.
5.Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest 2005;115:3378-384.
6. Coppinger JA, Cagney G, Toomey S, et al. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood 2004;103:2096-2104.
7.Akinsegun A, Akinola Olusola D, Sarah JO, et al. Mean platelet volume and platelet counts in type 2 diabetes: mellitus on treatment and non-diabetic mellitus controls in Lagos, Nigeria. Pan Afr Med J.2014;18:42.
8.Kodiatte TA, Manikyam UK, Rao SB, Jagadish TM, Reddy M, Lingaiah HK and Lakshmaiah V. Mean platelet volume in Type 2 diabetes mellitus. J Lab Physicians 2012; 4: 5-9.
9.Ulutas KT, Dokuyucu R, Sefil F, Yengil E, Sumbul AT, Rizaoglu H, et al. Evaluation of mean platelet volume in patients with type 2 diabetes mellitus and blood glucose regulation: a marker for atherosclerosis. Int J Clin Exp Med. 2014;7(4):955–61.
10.Ozder A, Eker HH. Investigation of mean platelet volume in patients with type 2 diabetes mellitus and in subjects with impaired fasting glucose: a cost-effective tool in primary health care. Int J Clin Exp Med.2014;7:2292–2297.
11.Coban E, Kucuktag S, Basyigit S. Platelet activation in subjects with impaired glucose tolerance. Platelets. 2007;18(8):591-594.
12.Dayal A, Kothari S, Shah RJ, Patel SM. Mean Platelet Volume In Diabetes Mellitus Type 2. APALM. 2016 Dec 15;3(6):A567-572
13.Shah B, Sha D, Xie D, Mohler ER 3rd and Berger JS. The relationship between diabetes, metabolic syndrome, and platelet activity as measured by mean platelet volume: The national health and nutrition examination surveys, 1999-2004. Diabetes Care 2012; 35:1074-1078.
14.Kim JH, Kang JI, Kim JW, Kim SY and Bae HY. The relationship between mean platelet volume and fasting plasma glucose differs with glucose tolerance status in a Korean population: Gender differences. Platelets 2013; 24:469-473.
15.Hekimsoy Z, Payzinb B, Ornek T, Kandogan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications. 2004;18(3):173–176.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 Umarani M K, Nikita James, Bharathi Muniyappa
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).