Adenoid cystic carcinoma of floor of the mouth with periumblical cutaneous metastasis
Keywords:
Adenoid cystic carcinoma, cutaneous metastasis, differential diagnosis, immune-histochemistryAbstract
Cutaneous metastasis from salivary gland adenoid cystic carcinoma (ACC) is extremely rare. We report a rare case of cutaneous metastasis from ACC of floor of the mouth. The presentation of cutaneous metastasis is nonspecific. Fine needle aspiration cytology becomes a quick and effective tool for the diagnosis in such cases. The clinical, histo-pathological differential diagnosis and immune-histochemical features are described and discussed. This brief report highlights the importance of clinical awareness of cutaneous metastasis after a long time lag which may mimic adnexal lesions.References
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2) Spiro RH: Distant metastasis in adenoid cystic carcinoma of salivary origin. Am J Surg 174:495-498, 1997
3) Ellis GL, Auclair P: Tumors of the salivary glands: Atlas of Tumor Pathology. Washington, DC: Armed Forces Institute of Pathology, 3rd Series, Fascicle 17, 1996
4) Perez DE, Magrin J, de Almeida OP, Kowalski LP. Multiple cutaneous metastases from a parotid adenoid cystic carcinoma. Pathol Oncol Res. 2007;13(2):167-9. Epub 2007 Jul 3.
5) Schwartz RA: Cutaneous metastatic disease. J Am Acad Dermatol 33:161-182, 1995
6) Kmucha ST, Troxel JM. Dermal metastasis in epidermoid carcinoma of the head and neck. Arch Otolaryngol Head Neck surg. 1993;119:326-30
7) Batson OV. The role of the vertebral veins in metastatic processes. Ann Intern Med. 1942;16:38-45
8) Jaso J, Malhotra R. Adenoid cystic carcinoma. Arch Pathol Lab Med. 2011 Apr;135(4):511-5. doi: 10.1043/2009-0527-RS.1.
9) Graça M. Dores, Mark M. Huycke, Susan S. Devesa, Carlos A. Garcia. Primary cutaneous adenoid cystic carcinoma in the United States: incidence, survival, and associated cancers, 1976-2005. J Am Acad Dermatol. 2010 Jul; 63(1): 71–78.
10) Holst VA, Marshall CE, Moskaluk CA and Frierson HF Jr: KIT protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma. Mod Pathol 12:956-960, 1999
11) Hotte SJ, Winquist EW, Lamont E, MacKenzie M, Vokes E, ChenEX, Brown S, Pond GR, Murgo A, Siu LL: Imatinib mesylate in patients with adenoid cystic cancers of the salivary glands expressing c-kit: A Princess Margaret Hospital phase II consortium study. J Clin Oncol 23:585-90, 2005
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02-05-2016
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Sinha R, Agrawal P, Singh AK. Adenoid cystic carcinoma of floor of the mouth with periumblical cutaneous metastasis. Ann of Pathol and Lab Med [Internet]. 2016 May 2 [cited 2024 Nov. 19];3(2):C60-63. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm507
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Copyright (c) 2016 Reena Sinha, Pallavi Agrawal, Akash Kumar Singh
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