CO-OCCCURENCE OF TWO DIFFERENT SUBTYPES OF RENAL CELL CARCINOMA IN A UNILATERAL HEALTHY KIDNEY
Keywords:
Renal cell carcinoma, clear cell carcinoma, papillary, translocation associated RCCAbstract
Renal cell carcinoma (RCC) is a malignant neoplasm of renal tubular origin of adult age group which presents as a mass in a kidney with abdominal pain and hematuria. There are various subtypes of RCC, each having distinct morphological features, prognosis and response to targeted therapy. Development of two RCC of different subtypes in the same kidney is rare because each RCC arises from a particular genetic abnormality. here we discuss two different RCC subtypes in a healthy kidney , one showing features of Papillary RCC and other showing mixed features with papillae formation and clear cells. Â
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2. Petrolla AA, MacLennan GT. Renal Cell Carcinoma and Other Concurrent Renal Neoplasms. The Journal of Urology. 2007;178:2163.
3. Eble JN, Togashi K, Pisani P: Renal cell carcinoma In: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs (JN Eble, G Sauter, JI Epstein, IA Sesterhenn Eds.) IARC Press, Lyon, 2004, pp. 12-14.
4. Licht M.R., Novick A.C., Tubbs R.R., Klein E.A., Levin H.S., Streem S.B. Renal oncocytoma: clinical and biological correlates. J Urol. 1993;150:1380–1383.
5. Jimenez RE, Eble JN, Reuter VE, Epstein JI, Folpe AL, de Peralta-Venturina M, Tamboli P, Ansell ID, Grignon DJ, Young RH, Amin MB: Concurrent angiomyolipoma and renal cell neoplasia: a study of 36 cases. Mod Pathol. 2001, 14: 157-163. 10.1038/modpathol.3880275.
6. Ross H, Martignoni G, Argani P. Renal cell carcinoma with clear cell and papillary features. Arch Pathol Lab Med. 2012;136:391–399.
7. Armah HB, Parwani A. Xp11.2 Translocation Renal Cell Carcinoma. Arch Pathol Lab Med 2010;134:124-29.
8. Zhong M, Osborne L, Merino MJ, Hameed M, Aisner S. The study of Xp11 translocation renal cell carcinoma (RCC) in adults by TMA, IHC and FISH [abstract]. Mod Pathol. 2010;23(suppl 1):232A.
9. Simhan J, Canter DJ, Sterious SN, Smaldone MC, Tsai KJ, Li T, et al. Pathological concordance and surgical outcomes of sporadic synchronous unilateral multifocal renal masses treated with partial nephrectomy. J Urol 2013;189:43-47.
10. E. Capaccio, V. Varca, A. Simonato, C. Toncini, G. Carmignani, and L. E. Derchi, “Synchronous parenchymal renal tumors of different histology in the same kidney,†Acta Radiologica, 2009, vol. 50 (10),1187–1192.
11. Ustuner M, Yaprak B, Teke K, Ciftci S, Kart M, Yildiz K, et al. Coexisting papillary and clear renal cell carcinoma in the same kidney. Case Rep Urol 2014;2014:575181
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05-11-2016
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Dhameja N, Goyal H, Aswal P, Dwivedi US. CO-OCCCURENCE OF TWO DIFFERENT SUBTYPES OF RENAL CELL CARCINOMA IN A UNILATERAL HEALTHY KIDNEY. Ann of Pathol and Lab Med [Internet]. 2016 Nov. 5 [cited 2024 Nov. 19];3(5):C241-245. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm705
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Copyright (c) 2016 Neeraj Dhameja, Hema Goyal, Priyanka Aswal, U S Dwivedi
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