Brunner’s gland hamartoma- A rare cause of upper gastro-intestinal bleed: report of two cases emphasising pathogenesis
Keywords:
Brunner’s gland, Hamartoma, Endoscopy, GastrointestinalAbstract
Brunner’s gland hamartoma (BGH) is a rare benign tumor of duodenum and mostly presents as an incidental finding. However, large lesions may cause obstructive symptoms and bleeding. Herein, we report two cases of BGH, one   with upper gastro-intestinal bleed and other with recurrent vomiting which were managed successfully by endoscopic resection.
References
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2. Sen R, Gupta V, Sharma N, Chawla N, Kumar S, Malik S. Brunner gland hamartoma masquerading as malignancy; a rare case report. Middle East J Dig Dis. 2014;6:237-40.
3. Peison B, Benisch B. Brunner’s gland adenoma of the duodenal bulb. Am J Gastroenterol. 1982;77:276-8.
4. Stolte M, Schwabe H, Prestele H. Relationship between diseases of the pancreas and hyperplasia of Brunner's glands. Virchows Arch A Pathol Anat Histol. 1981;394:75-87.
5. Kovacevic I, Ljubicic N, Cupic H et al. Helicobacter pylori infection in patients with Brunner’s gland adenoma. Acta Med Croatica. 2001;55:157–160.
6. Kim K, Jang SJ, Song HJ, Yu E. Clinicopathologic characteristics and mucin expression in Brunner’s gland proliferating lesions. Dig Dis Sci. 2013;58:194–201.
7. Sakurai T, Sakashita H, Honjo G, Kasyu I, Manabe T. Gastric foveolar metaplasia with dysplastic changes in Brunner gland hyperplasia: possible precursor lesions for Brunner gland adenocarcinoma. Am J Surg Pathol. 2005; 29:1442–1448.
8. Akaki M, Taniguchi S, Hatakeyama K, Kushima R, Kataoka H. Duodenal mucosal damage is associated with proliferative activity of Brunner's gland hamartoma: a case report. BMC Gastroenterol. 2014;14:14.
9. Chong KC, Cheah WK, Lenzi JE, Goh PM. Benign duo¬denal tumours. Hepatogastroenterology. 2000;47:1298-1300.
10. Zanetti G, Casadei G. Brunner’s gland hamartoma with incipient ductal malignancy: report of a case. Tumori. 1981;67:75-8.
2. Sen R, Gupta V, Sharma N, Chawla N, Kumar S, Malik S. Brunner gland hamartoma masquerading as malignancy; a rare case report. Middle East J Dig Dis. 2014;6:237-40.
3. Peison B, Benisch B. Brunner’s gland adenoma of the duodenal bulb. Am J Gastroenterol. 1982;77:276-8.
4. Stolte M, Schwabe H, Prestele H. Relationship between diseases of the pancreas and hyperplasia of Brunner's glands. Virchows Arch A Pathol Anat Histol. 1981;394:75-87.
5. Kovacevic I, Ljubicic N, Cupic H et al. Helicobacter pylori infection in patients with Brunner’s gland adenoma. Acta Med Croatica. 2001;55:157–160.
6. Kim K, Jang SJ, Song HJ, Yu E. Clinicopathologic characteristics and mucin expression in Brunner’s gland proliferating lesions. Dig Dis Sci. 2013;58:194–201.
7. Sakurai T, Sakashita H, Honjo G, Kasyu I, Manabe T. Gastric foveolar metaplasia with dysplastic changes in Brunner gland hyperplasia: possible precursor lesions for Brunner gland adenocarcinoma. Am J Surg Pathol. 2005; 29:1442–1448.
8. Akaki M, Taniguchi S, Hatakeyama K, Kushima R, Kataoka H. Duodenal mucosal damage is associated with proliferative activity of Brunner's gland hamartoma: a case report. BMC Gastroenterol. 2014;14:14.
9. Chong KC, Cheah WK, Lenzi JE, Goh PM. Benign duo¬denal tumours. Hepatogastroenterology. 2000;47:1298-1300.
10. Zanetti G, Casadei G. Brunner’s gland hamartoma with incipient ductal malignancy: report of a case. Tumori. 1981;67:75-8.
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Published
03-10-2016
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1.
Gupta RK, Saran RK, Varakanahalli S, Puri AS. Brunner’s gland hamartoma- A rare cause of upper gastro-intestinal bleed: report of two cases emphasising pathogenesis. Ann of Pathol and Lab Med [Internet]. 2016 Oct. 3 [cited 2025 Feb. 6];3(4):C190-193. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm808
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Case Report
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Copyright (c) 2016 Rakesh Kumar Gupta, Ravindra Kumar Saran, Shivakumar Varakanahalli, Amarender Singh Puri
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