Lepromatous Lymphadenitis: A Rare Manifestation of Leprosy Diagnosed by Fine Needle Aspiration Cytology

Authors

  • Falguni Chitkara Department of Pathology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Maharishi Markandeshwar Deemed to be University, Mullana-Ambala, Haryana, India.
  • Diljot Pannu Department of Pathology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Maharishi Markandeshwar Deemed to be University, Mullana-Ambala, Haryana, India.
  • Debkanya Saha Department of Pathology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Maharishi Markandeshwar Deemed to be University, Mullana-Ambala, Haryana, India.
  • Amay Makhija Department of Medicine, Maharishi Markandeshwar Institute of Medical Sciences and Research, Maharishi Markandeshwar Deemed to be University, Mullana-Ambala, Haryana, India.
  • Irbinder Kour Department of Pathology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Maharishi Markandeshwar Deemed to be University, Mullana-Ambala, Haryana, India.
  • Vishesh Dhawan Department of Pathology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Maharishi Markandeshwar Deemed to be University, Mullana-Ambala, Haryana, India.
  • Ayushi Kediya Department of Pathology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Maharishi Markandeshwar Deemed to be University, Mullana-Ambala, Haryana, India.

DOI:

https://doi.org/10.21276/apalm.3483

Keywords:

Leprosy FNAC, lymph node, slit skin smear

Abstract

Introduction: Leprosy is a widespread infectious and contagious disease with a prevalence rate of 0.4 per 10,000 population in India. It is a chronic infectious disease caused by Mycobacterium leprae and mainly affects the skin, the peripheral nerves, the mucosa of the upper respiratory tract, and the eyes. Lymph node involvement is rare.
Case Description: A 24-year-old male presented with right lower limb numbness for one year and a non-healing knee ulcer for one month, along with recurrent ulcers. sensory loss, and erythematous macules. Nerve conduction studies showed that the bilateral ulnar and sural nerves were non-excitable, and the median nerves had reduced amplitude. FNAC of a right inguinal lymph node revealed foamy macrophages and ill-defined granulomas; Modified Ziehl-Neelsen stain demonstrated numerous acid-fast bacilli, indicating lepromatous lymphadenitis. A punch biopsy from the knee ulcer showed epithelioid granulomas, foamy macrophages, and a Grenz zone with positive AFB staining. A diagnosis of Borderline Lepromatous (BL) leprosy was confirmed. The patient was started on multidrug therapy and showed clinical improvement.
Conclusion: When Leprosy presents as lymphadenopathy, FNAC can be a very useful tool for the diagnosis of Lymphadenopathy due to Leprosy and excludes other possibilities of Lymphadenitis. It is also a simpler, quicker, and less invasive technique for diagnosing such rare lesions.

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Published

20-09-2025

How to Cite

1.
Chitkara F, Pannu D, Saha D, Makhija A, Kour I, Dhawan V, et al. Lepromatous Lymphadenitis: A Rare Manifestation of Leprosy Diagnosed by Fine Needle Aspiration Cytology. Ann of Pathol and Lab Med [Internet]. 2025 Sep. 20 [cited 2025 Dec. 5];12(9):C143-C146. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/3483

Issue

Vol. 12 No. 9 (2025)

Section

Case Report

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Copyright (c) 2025 Falguni Chitkara, Diljot Pannu, Debkanya Saha, Amay Makhija , Irbinder Kour, Vishesh Dhawan , Ayushi Kediya

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