Diagnostic Impact of USG-Guided FNAC in Liver Lesions: A Retrospective Study

Authors

  • Renuka Verma Department of Pathology, PT. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India
  • Anjali Ahalawat Department of Pathology, PT. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India
  • Chanchal Department of Pathology, PT. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India
  • Usha Rani Department of Pathology, PT. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India
  • Nisha Marwah Department of Pathology, PT. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India
  • Rajnish Kalra Department of Pathology, PT. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India
  • Sunita Singh Department of Pathology, PT. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India

DOI:

https://doi.org/10.21276/apalm.3492

Keywords:

FNAC, liver, USG-guided, diagnosis

Abstract

Background: Ultrasound-guided fine-needle aspiration cytology (FNAC) has emerged as a pivotal diagnostic tool in the evaluation of liver lesions, offering a minimally invasive, accurate, and efficient method for obtaining tissue samples. This article aims to provide a comprehensive overview of the spectrum of liver lesions diagnosed through USG-guided FNAC in our tertiary care facility, highlighting its diagnostic efficacy, clinical impact, and potential challenges.

Materials and Methods: This is a retrospective study conducted over a period of 18 months in Post Graduate Institute of Medical Sciences, Rohtak, a tertiary care hospital and medical institute. All the liver lesions undergoing USG-guided FNAC were included in the study.

Results: A total of 188 cases were included in the study. The age of patients ranged from 20–87 years, with a male-to-female ratio of 1.7:1. On cytological characterization, 72.9% were malignant, 0.5% were benign, 14.4% were reported as non-neoplastic, and 12.2% were inadequate or unsatisfactory for opinion. Among the malignant lesions, poorly differentiated carcinoma was the most commonly diagnosed malignant lesion.

Conclusion: In the complex clinical landscape of a tertiary care hospital, where patients present with a broad spectrum of hepatic pathologies, the utility of USG-guided FNAC cannot be overstated.

References

1. Kumar PB, Hegde P, Kumar BN, Kumar ML, Manjunath YC. A comparative study of ultrasound and CT findings in focal liver lesions. Int J Biol Med Res. 2014;5(3):4362–9.

2. Bajantri SR, Mehta DP, Shah PC, Patel RA. Ultrasound guided fine needle aspiration cytology in deep seated lesions: an effective diagnostic tool. Int J Res Med Sci. 2022;10:2800–4.

3. Hemalatha AL, Sindhuram VS, Sushma S, Suma JK, Varna I, Aditya A. Ultrasound guided FNAC of abdominal–pelvic masses – the pathologists’ perspective. J Clin Diagn Res. 2013;7(2):273–7.

4. Swamy CM, Arathi CA, Kodandaswamy CR. Value of ultrasonography-guided fine needle aspiration cytology in the investigative sequence of hepatic lesions with an emphasis on hepatocellular carcinoma. J Cytol. 2011;28:178–84.

5. Talukder SI, Huq MH, Haque MA, Rahman S, Islam SM, Hossain GA, et al. Ultrasound guided fine needle aspiration cytology for diagnosis of mass lesions of liver. Mymensingh Med J. 2004;13:25–9.

6. Bohara S, Shukla P, Shah S, Chaturvedi R, Singh K. Utility of guided FNAC and cell block preparation from liver and gall bladder masses: learning experience from a tertiary care center. J Cancer Res Ther. [Year unknown];0(0):0.

7. Nazir RT, Sharif MA, Iqbal M, Amin MS. Diagnostic accuracy of fine needle aspiration cytology in hepatic tumors. J Coll Physicians Surg Pak. 2010;20:373–6.

8. Meena SP, Patangia P, Rai NN. Diagnostic utility of USG-guided FNAC in hepatic lesions. J Evid Based Med Healthc. 2016;3(52):2699–702.

9. Vyas JV, Patel PR, Patel K, Bhagat VM. Cytomorphological study of hepatic lesions by FNAC. Ann Pathol Lab Med. 2022;9(3):A68–74.

10. Mishra D, Choudhary S, Verma N, Meena A, Dhayal S. Role of ultrasound guided fine needle aspiration cytology in the diagnosis of space occupying lesions of liver. Int J Pharm Clin Res. 2022;14(2):265–71.

11. Lekha MB, Prabhu DC, Nagarjappa AH. Ultrasound/computerized guided fine needle aspiration cytology of liver lesions. IP J Diagn Pathol Oncol. 2018;3(2):68–74.

12. Agrarwal A, Khandelwal R, Singh SN, Pant H, Gupta AK. Evaluation of guided gene needle aspiration cytology in the diagnosis of hepatic lesions. Int J Biomed Res. 2017;8(2):75–80.

13. Goel S, Hemrajani D, Sharma M. Ultrasound guided fine needle aspiration cytology (FNAC) in diagnosis of space occupying lesions (SOL) of liver. J Evol Med Dent Sci. 2014;3(27):7480–6.

14. Philipose CS, Amin AN, CS J. Computed tomography and ultrasound guided fine needle aspiration cytology in the diagnosis of intraabdominal and pelvic lesions. Ann Pathol Lab Med. 2018;5(9):A754–8.

15. Glaxon JA, Saldanha P, Vasudevan S. Utility of USG-guided fine needle aspiration cytology in diagnosis of intra-abdominal masses. Ann Pathol Lab Med. 2018;5(5):A349–53.

16. Reddy S, Andola SK. FNAC of intra-abdominal lesions. J Clin Diagn Res. 2011;5(4):758–65.

17. Asghar F, Riaz S. Diagnostic accuracy of percutaneous cytodiagnosis of hepatic masses by ultrasound guided fine needle aspiration cytology. Ann King Edward Med Univ. 2010;16(3):184–8.

18. Verma N, Neetu, Sharma SP, Singh P, Kumar A. Role of ultrasound guided fine needle aspiration cytology of right hypochondrial masses. Int J Res Med Sci. 2017;5(12):5312.

19. Barbhuiya M, Bhunia S, Kakkar M, Shrivastava B, Tiwari P, Gupta S, et al. Role of fine needle aspiration cytology in the diagnosis of intra-abdominal lumps. J Evol Med Dent Sci. 2014;3(1):20–4.

20. Nasit JG, Patel V, Parikh B, Shah M, Davara K. Fine needle aspiration cytology and biopsy in hepatic masses: a minimally invasive diagnostic approach. Clin Cancer Investig J. 2013;2:132–42.

21. Nautiyal S, Mishra RK, Sharma SP. Routine and ultrasound guided FNAC of intraabdominal lumps – a comparative study. J Cytol. 2004;21(3):129–32.

22. Mahale R, Namdeo R, Meeravi J, Thakre S, Shrivastava V. Role of ultrasound guided fine needle aspiration cytology in hepatic lesions: a prospective and observational study at a tertiary health care centre in central India. Asian J Pharm Clin Res. 2023;16(4):89–92.

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Published

31-05-2025

How to Cite

1.
Verma R, Ahalawat A, Chanchal, Rani U, Marwah N, Kalra R, et al. Diagnostic Impact of USG-Guided FNAC in Liver Lesions: A Retrospective Study. Ann of Pathol and Lab Med [Internet]. 2025 May 31 [cited 2025 Jul. 26];12(5):A113-122. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/3492

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