Papillary Cystadenoma of the Epididymis
DOI:
https://doi.org/10.21276/apalm.3600Keywords:
Papillary, Von Hippel-Lindau Disease, Epididymis, CystadenomaAbstract
Papillary cystadenoma of epididymis (PCE) is a benign neoplasm involving epididymis and frequently associated with Von Hippel-Lindau (VHL) disease. It is characterized by asymptomatic swelling, which is well circumscribed with papillary fronds on cut section. On microscopic examination, numerous cystic spaces with papillary infoldings are seen. These infoldings are covered with cuboidal to columnar epithelium. It is important to excise and do histopathological examination to rule out diagnosis of serous cystadenocarcinoma of paratestis, which mimic in symptomatology to papillary cystadenoma of epididymis but has poor prognosis. At the same time, regular ultrasonography done to rule out renal cell carcinoma as this entity is associated with VHL disease.
References
1. Odrzywolski KJ, Mukhopadhyay S. Papillary cystadenoma of the epididymis. Arch Pathol Lab Med. 2010 Apr;134(4):630-3.
2. Vijayvargiya M, Jain D, Mathur SR, Iyer VK. Papillary cystadenoma of the epididymis associated with von Hippel-Lindau disease diagnosed on fine needle aspiration cytology. Cytopathology. 2014 Aug 25(4):279-81.
3. Lopez O, Bahmad HF, Delgado R, Cordon BH, Poppiti R, Howard L. Autops Case Rep. 2022 Apr 14:12:e2021374.
4. Sherrick JC. Papillary cystadenoma of the epididymis. Cancer. 1956 Mar-Apr;9(2):403-7.
5. Iczkowski KA, Pantazis CG. Papillary cystadenofibroma of epididymis: a case report. Int J Clin Exp Pathol. 2011 Aug 15;4(6):629-31.
6. Ghasemi Shektaie SH, Shafi H. Falahi A, Mahmoudlou F. Moudi E. Caspian J Intern Med. 2021:12(Suppl 2):S388-91.
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Copyright (c) 2025 Meghana Yadav, Deepti Agarwal, Kulwant Singh, Parveen Rana Kundu, Sunaina Hooda, Swaran Kaur

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