Clinical and Histopathological Correlation in Hansen's Disease
Keywords:
Clinical diagnosis, Histopathological diagnosis, Leprosy, Fite Faraco stain, agreement, disagreement.Abstract
BACKGROUND: The present study was carried out to correlate clinical diagnosis of new leprosy cases with that of histopathological diagnosis of skin biopsies stained with Haematoxylin and Eosin followed by Fite Faraco stain.
METHOD: Skin biopsies of 70 newly diagnosed leprosy patients were fixed in 10% formalin and routine histopathological examination done followed by special stain ( Fite Faraco ) to evaluate the bacterial index.
RESULTS: From this study it was observed that, the commonest age group affected by leprosy was 31 to 50 years, males are twice more commonly affected than females ( M:F = 1.9 : 1 ) and the most commonest clinically diagnosed spectrum was Tuberculoid leprosy ( TT ). The commonest histopathologically diagnosed spectrum was Indeterminate leprosy( IL ). It was observed that there was complete agreement between clinical diagnosis and histopathological diagnosis in 62.85% cases and disagreement was observed in 37.15% cases.
CONCLUSION: In case of confirmed discrepancy, the more advanced findings ( ie. towards the lepromatous pole ) should be given greater weightage and the case is to be classified and treated accordingly.
DOI: 10.21276/APALM.1462
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Copyright (c) 2017 Muruganantham Arunagirinathan, Vennila Muniswamy, Sivaraman Jeevirathinam
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