Clinical and Histopathological Correlation in Hansen’s Disease

Authors

  • Muruganantham Arunagirinathan GOVERNMENT VELLORE MEDICAL COLLEGE AND HOSPITAL, VELLORE. TAMIL NADU, INDIA.
  • Vennila Muniswamy GOVERNMENT VELLORE MEDICAL COLLEGE & HOSPITAL, VELLORE.
  • Sivaraman Jeevirathinam GOVERNMENT VELLORE MEDICAL COLLEGE & HOSPITAL, VELLORE.

Keywords:

Clinical diagnosis, Histopathological diagnosis, Leprosy, Fite Faraco stain, agreement, disagreement.

Abstract

BACKGROUND: The  present  study  was  carried out  to  correlate  clinical  diagnosis  of  new  leprosy  cases  with  that  of  histopathological  diagnosis  of  skin  biopsies  stained  with  Haematoxylin  and  Eosin  followed  by  Fite  Faraco  stain.

METHOD: Skin  biopsies of  70 newly  diagnosed  leprosy  patients  were  fixed  in  10% formalin  and  routine  histopathological  examination done  followed  by  special  stain ( Fite  Faraco )  to  evaluate  the  bacterial  index. 

RESULTS: From  this  study  it  was  observed  that,  the  commonest  age  group  affected  by  leprosy  was  31  to  50  years,  males  are  twice  more  commonly  affected  than  females ( M:F = 1.9 : 1 )  and  the  most  commonest  clinically  diagnosed  spectrum  was  Tuberculoid leprosy  ( TT ).  The  commonest  histopathologically  diagnosed  spectrum  was  Indeterminate  leprosy( IL ). It  was  observed  that  there  was  complete  agreement  between  clinical  diagnosis  and  histopathological  diagnosis  in  62.85%  cases  and  disagreement was  observed  in  37.15%  cases.

CONCLUSION: In  case  of  confirmed   discrepancy,  the  more  advanced  findings ( ie.  towards  the  lepromatous  pole )  should  be  given  greater  weightage  and  the  case  is  to  be  classified  and  treated  accordingly.

 

DOI: 10.21276/APALM.1462

Author Biographies

Muruganantham Arunagirinathan, GOVERNMENT VELLORE MEDICAL COLLEGE AND HOSPITAL, VELLORE. TAMIL NADU, INDIA.

DEPARTMENT OF PATHOLOGY, ASSISTANT  PROFESSOR.

Vennila Muniswamy, GOVERNMENT VELLORE MEDICAL COLLEGE & HOSPITAL, VELLORE.

DEPARTMENT  OF  PATHOLOGY,

ASSISTANT  PROFESSOR

Sivaraman Jeevirathinam, GOVERNMENT VELLORE MEDICAL COLLEGE & HOSPITAL, VELLORE.

DEPARTMENT  OF  PATHOLOGY,

ASSISTANT  PROFESSOR

References

1. Jopling WH, McDougall. Definition, Epidemiology and World Distribution Hand book of Leprosy, Fifth edition. CBS Publishers and Distributors 1996: 1.
2. National Leprosy Eradication Programme – Annual report for the year 2015 -2016.
3.WHO – Fact sheet on Leprosy : Status of the disease in 2015.
4. Ridley DS, Jopling WH. Classification of leprosy accroding to immunity: a five- group ystem. Int J Lepr 1966; 34: 255.
5. Mitra K, Biswas S et al. Correlation between clinical and histopathological criteria for the classification of leprosy. Indian J Dermatol 2001; 46 ( 3) :135- 137.
6. Nadia S, Rashmi J, Sohaib A, Rawat SDS, Selvi Thamarai N, Meena H. Clinicopathological correlation of Leprosy : A 4 year’s retrospective study from a tertiary referral centre in North India. Int J Med Res Health Sci. 2015;4(2):350-354.
7. Shenoi SD, Siddappa K. Correlation of clinical and histopathologic features in untreated macular lesions of leprosy - a study of 100 cases. Ind J Lepr 1988; 60 : 202 - 06.
8. Pandey AN, Tailor HJ. Clinicohistopathological correlation of leprosy. Ind J Dermatol Venereol Lep 2008; 74 : 74- 76.
9.Bhatia AS, Katoch K et al. Clinical and histopathological correlation in the classification of leprosy. Ind J Lepr 1993 ; 61 : 433- 438.
10.Kalla G, Salodkar A, Kachhawwa D. Clinical and histopathological correlation in leprosy. Ind J Lepr 2000 ; 68 : 184 -185.
11.Shanker Narayan NP, Ramu G et al. Correlation of clinical, histological and immunological features across the leprosy spectrum. Ind J Lepr 2001 ; 73 :329- 42.
12. Nadkarni NS, Rege VL. Significance of histopathological classification in leprosy. Ind J Lepr 1999 ; 7 : 325- 32.
13.Singhi MK, Kachhawa D, Ghiya BC. A retrospective study of clinic- histological correlation in leprosy. Ind J Pathol Microbiol 2003 ; 46 : 47- 48.
14.Sandeep M, Shamanur Murugesh. A Study of Clinic-Pathological Concordance in Leprosy Patients in the Post-Elimination Era. International Journal of Science and Research. 2016;5(2):1304-1306.

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Published

31-08-2017

How to Cite

1.
Arunagirinathan M, Muniswamy V, Jeevirathinam S. Clinical and Histopathological Correlation in Hansen’s Disease. Ann of Pathol and Lab Med [Internet]. 2017 Aug. 31 [cited 2024 Dec. 21];4(4):A454-459. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm1462

Issue

Vol. 4 No. 4 (2017)

Section

Original Article

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Copyright (c) 2017 Muruganantham Arunagirinathan, Vennila Muniswamy, Sivaraman Jeevirathinam

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